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Literature summary for 3.4.11.20 extracted from

  • McGowan, S.; Oellig, C.A.; Birru, W.A.; Caradoc-Davies, T.T.; Stack, C.M.; Lowther, J.; Skinner-Adams, T.; Mucha, A.; Kafarski, P.; Grembecka, J.; Trenholme, K.R.; Buckle, A.M.; Gardiner, D.L.; Dalton, J.P.; Whisstock, J.C.
    Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases (2010), Proc. Natl. Acad. Sci. USA, 107, 2449-2454.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged truncated form expressed in Escherichia coli Rosetta2 BL21(DE3) Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
Plasmodium falciparum
EDTA
-
Plasmodium falciparum
hPhe-PSI[PO2CH2]-Phe phosphinic dipeptide analog Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8IL11
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography (Ni2+), gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-7-amido-4-methyl-coumarin + H2O
-
Plasmodium falciparum L-leucine + 7-amino-4-methyl-coumarin
-
?

Subunits

Subunits Comment Organism
homohexamer crystal structure analysis Plasmodium falciparum

Synonyms

Synonyms Comment Organism
M17 leucyl aminopeptidase
-
Plasmodium falciparum
PfA-M17
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000013
-
hPhe-PSI[PO2CH2]-Phe pH and temperature not specified in the publication Plasmodium falciparum
0.000025
-
bestatin pH and temperature not specified in the publication Plasmodium falciparum