Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-phenyl-butyl)-amide | - |
Plasmodium falciparum | |
1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 4-fluoro-benzylamide | - |
Plasmodium falciparum | |
2-(4-benzyl-piperidine-1-carbonyl)-4-methyl-pentanoic acid hydroxyamide | - |
Plasmodium falciparum | |
2-benzyl-3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
2-benzyl-3-(4-benzyl-piperazin-1-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
2-benzyl-3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
2-benzyl-N-(2,2-diphenyl-ethyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-(4-chloro-benzyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-(4-fluoro-benzyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-indan-2-yl-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-naphthalen-1-ylmethyl-malonamide | - |
Plasmodium falciparum | |
2-benzyl-N-hydroxy-N'-phenethyl-malonamide | - |
Plasmodium falciparum | |
2N-dibenzyl-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-2-(3-phenoxy-benzyl)-propionamide | - |
Plasmodium falciparum | |
3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-2-(3-phenoxybenzyl)-propionamide | - |
Plasmodium falciparum | |
N-(4-chloro-benzyl)-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
N-(4-chloro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | - |
Plasmodium falciparum | |
N-(4-fluoro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | - |
Plasmodium falciparum | |
N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(E)-ylidene]-malonamide | - |
Plasmodium falciparum | |
N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | - |
Plasmodium falciparum | |
N-benzyl-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
N-benzyl-N'-hydroxy-2-isobutyl-malonamide | in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | |
N-hydroxy-2-(3-phenoxy-benzyl)-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-trifluoromethyl-benzyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-(1,2,3,4-tetrahydro-naphthalen-1-yl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-naphthalen-1-ylmethyl-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-2-isobutyl-N'-phenethyl-malonamide | - |
Plasmodium falciparum | |
N-hydroxy-N'-(4-phenyl-butyl)-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Plasmodium falciparum FcB1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Leu-p-nitroanilide + H2O | - |
Plasmodium falciparum | L-Leu + p-nitroaniline | - |
? | |
L-Leu-p-nitroanilide + H2O | - |
Plasmodium falciparum FcB1 | L-Leu + p-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PfA-M1 | belongs to the M1 family and displays a strict aminopeptidase activity at pH 7.4 and a broad substrate spectrum | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000006 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | |
0.000013 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-N'-(4-phenyl-butyl)-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | |
0.000027 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(4-fluoro-benzyl)-N'-hydroxy-malonamide | |
0.000041 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide | |
0.000045 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(3-phenoxy-benzyl)-malonamide | |
0.000046 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide | |
0.000091 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-naphthalen-1-ylmethyl-malonamide | |
0.000107 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-naphthalen-1-ylmethyl-malonamide | |
0.000109 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(1,2,3,4-tetrahydro-naphthalen-1-yl)-malonamide | |
0.000125 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2N-dibenzyl-N'-hydroxy-malonamide | |
0.000125 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(3-phenyl-propyl)-malonamide | |
0.00013 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-chloro-benzyl)-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | |
0.000164 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-benzyl-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | |
0.00017 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(4-chloro-benzyl)-N'-hydroxy-malonamide | |
0.000206 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-propionamide | |
0.000225 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-phenyl-butyl)-malonamide | |
0.000231 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-trifluoromethyl-benzyl)-malonamide | |
0.000248 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-2-(3-phenoxybenzyl)-propionamide | |
0.000253 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-propionamide | |
0.00033 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(E)-ylidene]-malonamide | |
0.000406 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-(4-benzyl-piperidine-1-carbonyl)-4-methyl-pentanoic acid hydroxyamide | |
0.000495 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-benzyl-N'-hydroxy-2-isobutyl-malonamide | |
0.000527 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(3-phenyl-propyl)-malonamide | |
0.00079 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | |
0.000885 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-phenethyl-malonamide | |
0.000904 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-chloro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | |
0.000966 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-2-(3-phenoxy-benzyl)-propionamide | |
0.001011 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-phenethyl-malonamide | |
0.001149 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(4-phenyl-butyl)-malonamide | |
0.001168 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide | |
0.00176 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(4-benzyl-piperazin-1-yl)-N-hydroxy-3-oxo-propionamide | |
0.001931 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-indan-2-yl-malonamide | |
0.002515 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(3-phenoxy-benzyl)-malonamide | |
0.003896 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | |
0.005363 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(2,2-diphenyl-ethyl)-N'-hydroxy-malonamide | |
0.01 | - |
IC50 above 0.01 mM, in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 4-fluoro-benzylamide | |
0.01 | - |
IC50 above 0.01 mM, in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-phenyl-butyl)-amide |