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Literature summary for 3.4.11.2 extracted from

  • Krishnamoorthy, M.; Achary, A.
    Exploration of Sitagliptin as a potential inhibitor for the M1 Alanine aminopeptidase enzyme in Plasmodium falciparum using computational docking (2013), Bioinformation, 9, 293-298.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4,7-dimethyl-1,10 phenanthroline
-
Plasmodium falciparum
9-(4-hydroxyphenyl)-1,10-phenanthroline
-
Plasmodium falciparum
alprazolam
-
Plasmodium falciparum
bestatin
-
Plasmodium falciparum
camptothecin
-
Plasmodium falciparum
dihydroergotamine
-
Plasmodium falciparum
ergotamine
-
Plasmodium falciparum
sitagliptin
-
Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.322
-
DL-Ala-2-naphthylamide pH and temperature not specified in the publication Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-Ala-2-naphthylamide + H2O
-
Plasmodium falciparum ?
-
?

Synonyms

Synonyms Comment Organism
M1 alanine aminopeptidase
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000152
-
sitagliptin pH and temperature not specified in the publication Plasmodium falciparum
0.00794
-
alprazolam pH and temperature not specified in the publication Plasmodium falciparum
0.0133
-
ergotamine pH and temperature not specified in the publication Plasmodium falciparum
0.02278
-
dihydroergotamine pH and temperature not specified in the publication Plasmodium falciparum
0.02724
-
4,7-dimethyl-1,10 phenanthroline pH and temperature not specified in the publication Plasmodium falciparum
0.077
-
9-(4-hydroxyphenyl)-1,10-phenanthroline pH and temperature not specified in the publication Plasmodium falciparum
0.088
-
camptothecin pH and temperature not specified in the publication Plasmodium falciparum
0.0988
-
bestatin pH and temperature not specified in the publication Plasmodium falciparum