Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.2 extracted from

  • Li, X.; Wang, J.; Li, J.; Wu, J.; Li, Y.; Zhu, H.; Fan, R.; Xu, W.
    Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I) (2009), Bioorg. Med. Chem., 17, 3053-3060.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)-2-hydroxybenzoic acid
-
Sus scrofa
(R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)benzoic acid
-
Sus scrofa
(R)-5-(2,4-difluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(2,5-dichlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(2-chloroethylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(2-nicotinoylhydrazinyl)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(3-bromobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(3-chloro-4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(3-iodobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-aminophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-bromo-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-bromophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-chloro-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-chlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-(4-nitrophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-oxo-5-(2-(thiazole-2-carbonyl)hydrazinyl)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-oxo-5-(thiazol-2-ylamino)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
-
Sus scrofa
(R)-5-oxo-5-4-[(1,3-thiazole-2-amino)sulfonyl]phenylamino-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
-
Sus scrofa
(R)-5-[4-(aminosulfonyl)phenylamino]-5-oxo-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
-
Sus scrofa
bestatin
-
Sus scrofa
N-(1-(2-aminophenyl)-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-p-nitroanilide + H2O
-
Sus scrofa L-Leu + p-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Sus scrofa
APN
-
Sus scrofa
CD13
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0131
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa bestatin
0.0234
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-aminophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0243
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.04
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-chlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0401
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-oxo-5-4-[(1,3-thiazole-2-amino)sulfonyl]phenylamino-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
0.0419
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-bromophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0456
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-chloro-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0512
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(4-bromo-2-fluorobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0578
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)-2-hydroxybenzoic acid
0.0658
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-4-(4-carboxy-2-(3,4,5-trimethoxybenzamido)butanamido)benzoic acid
0.0659
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(3-iodobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0724
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(2-nicotinoylhydrazinyl)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0785
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(3-chloro-4-fluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0804
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(2,5-dichlorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0877
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-oxo-5-(2-(thiazole-2-carbonyl)hydrazinyl)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.0896
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(2,4-difluorophenylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.1026
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-[4-(aminosulfonyl)phenylamino]-5-oxo-4-[(3,4,5-trimethoxybenzamido)]pentanoic acid
0.104
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa N-(1-(2-aminophenyl)-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide
0.1076
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-oxo-5-(thiazol-2-ylamino)-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.1769
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(3-bromobenzylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid
0.805
-
in 50 mM PBS, pH 7.2 at 37°C Sus scrofa (R)-5-(2-chloroethylamino)-5-oxo-4-(3,4,5-trimethoxybenzamido)pentanoic acid