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Literature summary for 3.4.11.2 extracted from

  • Shang, L.; Wang, Q.; Fang, H.; Mu, J.; Wang, X.; Yuan, Y.; Wang, B.; Xu, W.
    Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN) (2008), Bioorg. Med. Chem., 16, 9984-9990.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
(2E)-N-[(2R)-2-amino-3-phenylpropyl]-3-(3,4-dihydroxyphenyl)-acrylamide hydrochloride
-
 Sus scrofa
(2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide hydrochloride
-
 Sus scrofa
(2S)-2,5-amino-N-[(2R)-2-amino-3-phenylpropyl]-valeramide hydrochloride
-
 Sus scrofa
(2S)-2,6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
-
 Sus scrofa
(2S)-2-amino-3-hydroxyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
 Sus scrofa
(2S)-2-amino-3-methyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
 Sus scrofa
(2S)-2-amino-3-thiol-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
 Sus scrofa
(2S)-2-amino-4-methyl-N-[(2R)-2-amino-3-phenylpropyl]valeramide hydrochloride
-
 Sus scrofa
(2S)-2-amino-4-methylthio-N-[(2R)-2-amino-3-phenylpropyl]butyramide hydrochloride
-
 Sus scrofa
(2S)-2-amino-N-[(2R)-2-amino-3-phenylpropyl]-propionamide hydrochloride
-
 Sus scrofa
2-amino-N-[(2R)-2-amino-3-phenylpropyl]acetamide hydrochloride
-
 Sus scrofa
3-amino-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
-
 Sus scrofa
6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
-
 Sus scrofa
bestatin
-
 Sus scrofa
L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-2-phenylacetamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-3,5-dinitrobenzamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-3-phenylpropanamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-4-phenylbutanamide hydrochloride
-
 Sus scrofa
N-[(2R)-2-amino-3-phenylpropyl]-L-glutamamide hydrochloride
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-p-nitroanilide + H2O
-
 Sus scrofa L-Leu + p-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
 Sus scrofa
APN
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0155
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa L-phenylalanyl-N-[(2R)-2-amino-3-phenylpropyl]-L-phenylalaninamide hydrochloride
0.0211
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-3-thiol-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
0.0337
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-3-hydroxyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
0.0505
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2,5-amino-N-[(2R)-2-amino-3-phenylpropyl]-valeramide hydrochloride
0.1187
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-4-methylthio-N-[(2R)-2-amino-3-phenylpropyl]butyramide hydrochloride
0.1424
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-4-methyl-N-[(2R)-2-amino-3-phenylpropyl]valeramide hydrochloride
0.162
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa bestatin
0.1642
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2,6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
0.1643
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa 6-amino-N-[(2R)-2-amino-3-phenylpropyl]caproylamide hydrochloride
0.2045
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-3,5-dinitrobenzamide hydrochloride
0.2895
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-3-phenylpropanamide hydrochloride
0.4086
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa 3-amino-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
0.476
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-3-methyl-N-[(2R)-2-amino-3-phenylpropyl]propionamide hydrochloride
0.4918
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2E)-N-[(2R)-2-amino-3-phenylpropyl]-3-(3,4-dihydroxyphenyl)-acrylamide hydrochloride
0.5958
-
 in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2E)-N-[(2R)-2-Amino-3-phenylpropyl]-3-phenylacrylamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa 2-amino-N-[(2R)-2-amino-3-phenylpropyl]acetamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa (2S)-2-amino-N-[(2R)-2-amino-3-phenylpropyl]-propionamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-L-glutamamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-2-phenylacetamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-4-phenylbutanamide hydrochloride
1
-
 IC50 above 1.0 mM, in 50 mM PBS, pH 7.2, at 37°C Sus scrofa N-[(2R)-2-amino-3-phenylpropyl]-2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetamide hydrochloride