Literature summary for 3.4.11.2 extracted from

Kehlen, A.; Geisler, M.; Olsen, J.; Sablotzki, A.; Langner, J.; Riemann, D.
IL-10 and TGF-beta differ in their regulation of aminopeptidase N/CD13 expression in monocytes (2004), Int. J. Mol. Med., 13, 877-882.

Search for more literature for 3.4.11.2

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, quantitativ expression analysis in monocytes and macrophages of percardial fluid	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	intergral	Homo sapiens	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc-metallopeptidase	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme plays a role in the modulation of kinins, neuropeptides, and chemotactic mediators as well as in adhesion and cell-cell interactions, it participates in antigen processing and presentation, trimming of peptides protrusing out of MHC class II molecules, and acts in inflammatory processes, interleukin-10 and TGF-beta are involved in enzyme upregulation in monocytes and U-937 cells, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	of peripheral blood, spleen and tonsils	Homo sapiens	-
macrophage	high enzyme expression, of percardial fluid	Homo sapiens	-
monocyte	of percardial fluid	Homo sapiens	-
additional information	quantitative expression analysis	Homo sapiens	-
U-937 cell	promonocytic cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala-4-nitroanilide + H2O	-	Homo sapiens	L-Ala + 4-nitroaniline	-	?
additional information	the enzyme plays a role in the modulation of kinins, neuropeptides, and chemotactic mediators as well as in adhesion and cell-cell interactions, it participates in antigen processing and presentation, trimming of peptides protrusing out of MHC class II molecules, and acts in inflammatory processes, interleukin-10 and TGF-beta are involved in enzyme upregulation in monocytes and U-937 cells, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase N	-	Homo sapiens
APN	-	Homo sapiens
CD13	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)