Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | competitive, moderate inhibition of keratinocyte growth | Homo sapiens | |
anti-CD13 antibody WM15 | enzyme blocking, commercial preparation | Homo sapiens | |
bestatin | competitive, low inhibition of keratinocyte growth | Homo sapiens | |
Substance P | competitive, high inhibition of keratinocyte growth | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
membrane | bound | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the inhibition of APN results in decreased growth of cultured keratinocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | nonstimulated from healthy skin, expression analysis, 100% expression of CD13, high density expression on the cell surface | Homo sapiens | - |
keratinocyte | nonstimulated from healthy skin, expression analysis, 30% of keratinocytes express CD13, lower density expression on the cell surface | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-2-naphthylamide + H2O | - |
Homo sapiens | L-Ala + 2-naphthylamine | - |
? | |
additional information | the inhibition of APN results in decreased growth of cultured keratinocytes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |