Literature summary for 3.4.11.2 extracted from

Fukasawa, K.; Fujii, H.; Saitoh, Y.; Koizumi, K.; Aozuka, Y.; Sekine, K.; Yamada, M.; Saiki, I.; Nishikawa, K.
Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis (2006), Cancer Lett., 243, 135-143.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	APN/CD13 plays multiple roles in morphogenesis during angiogenesis in vascular endothelium, enzyme inhibition by RNAi results in inhibition of capillary tube formation of umbilical vein endothelil cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15144	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	endothelial cell	Homo sapiens	-
umbilical vein	endothelial cell	Homo sapiens	-
vascular endothelial cell	selective expression of APN/CD13	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	APN/CD13 plays multiple roles in morphogenesis during angiogenesis in vascular endothelium, enzyme inhibition by RNAi results in inhibition of capillary tube formation of umbilical vein endothelil cells	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
aminopeptidase N	-	Homo sapiens
APN	-	Homo sapiens
CD13	-	Homo sapiens

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Release 2023.1 (January 2023)