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Literature summary for 3.4.11.2 extracted from

  • Aozuka, Y.; Koizumi, K.; Saitoh, Y.; Ueda, Y.; Sakurai, H.; Saiki, I.
    Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice (2004), Cancer Lett., 216, 35-42.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bestatin inhibits the enzyme, and the melanoma cell-induced angiogenesis in a dorsal air sac assay after oral administration to mice, intraperitoneal administration after orthotopic implantation of B16-B16 melanoma cells into mice reduces the number of vessels oriented towards the established primary tumor on the dorsal side Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane anchored by its N-terminal segment Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-metallopeptidase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
female C57BL/8 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-BL6 cell melanoma cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-7-amido-4-methylcoumarin + H2O
-
Mus musculus L-Ala + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Mus musculus
APN
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus