Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide] | PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM | Sus scrofa | |
bestatin | transition state analogue of Phe-Leu, competitive | Sus scrofa | |
additional information | no inhibition by psammaplin A analogues psammaplin B, psammaplin C, psammaplin A-1, psammaplin C-1, and psammplin D | Sus scrofa | |
psammaplin A | - |
Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-metallopeptidase | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | the enzyme plays a key role in tumor cell invasion and angiogenesis, enzyme inhibition by psammaplin A suppresses the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor, and proliferation of cancer and endothelial cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-7-amido-4-methylcoumarin + H2O | - |
Sus scrofa | L-Ala + 7-amino-4-methylcoumarin | - |
? | |
additional information | the enzyme plays a key role in tumor cell invasion and angiogenesis, enzyme inhibition by psammaplin A suppresses the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor, and proliferation of cancer and endothelial cells, overview | Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Sus scrofa |
APN | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
psammaplin A | pH 7.4, 37°C | Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.018 | - |
PsA, isolated from a marine sponge, inhibits the enzyme non-competitively and suppresses angiogenesis in vitro, IC50 is 0.018 mM | Sus scrofa | (2E,2'E)-N,N'-[disulfanediyldi(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanamide] |