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Literature summary for 3.4.11.2 extracted from

  • Iturrioz, X.; Reaux-Le Goazigo, A.; Llorens-Cortes, C.
    Aminopeptidase inhibitors as anti-hypertensive drugs (2004), Aminopeptidases in Biology and Disease (Hooper, N. M. ; Lendechel, U. , eds. ), 2, 229-250.
No PubMed abstract available

Application

Application Comment Organism
pharmacology the enzyme is a target for design of inhibitors acting as anti-hypertensive drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
amastatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Homo sapiens
bestatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Homo sapiens
EC27 selective APN inhibitor Homo sapiens
additional information enzyme inhibitors can act as anti-hypertensive drugs Homo sapiens
PC18 selective APN inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin III + H2O Homo sapiens the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview angiotensin IV + Arg
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Homo sapiens angiotensin IV + Arg
-
ir
angiotensin III + H2O i.e. Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens angiotensin IV + Arg i.e. Val-Tyr-Ile-His-Pro-Phe ir

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Homo sapiens
APN
-
Homo sapiens