Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for design of inhibitors acting as anti-hypertensive drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amastatin | inhibits the enzyme and blocks the metabolism of brain angiotensin II and III | Homo sapiens | |
bestatin | inhibits the enzyme and blocks the metabolism of brain angiotensin II and III | Homo sapiens | |
EC27 | selective APN inhibitor | Homo sapiens | |
additional information | enzyme inhibitors can act as anti-hypertensive drugs | Homo sapiens | |
PC18 | selective APN inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin III + H2O | Homo sapiens | the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview | angiotensin IV + Arg | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin III + H2O | the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview | Homo sapiens | angiotensin IV + Arg | - |
ir | |
angiotensin III + H2O | i.e. Arg-Val-Tyr-Ile-His-Pro-Phe | Homo sapiens | angiotensin IV + Arg | i.e. Val-Tyr-Ile-His-Pro-Phe | ir |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
APN | - |
Homo sapiens |