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Literature summary for 3.4.11.2 extracted from
- Glutathione-degrading enzymes of microvillus membranes (1982), J. Biol. Chem., 257, 6322-6327.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | no significant inhibition by thiol compounds | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
L-alpha-aminobutyryl-Gly | - |
Rattus norvegicus | |
| 2.5 | - |
Cys-Gly | - |
Rattus norvegicus | |
| 3.4 | - |
Ala-Gly | - |
Rattus norvegicus | |
| 4.8 | - |
L-cystinyl-bis-Gly | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aminoacyl peptide | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epididymis | - |
Rattus norvegicus | - |
| jejunum | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.6 | - |
L-cystinyl-bis-Gly as substrate | Rattus norvegicus |
| 6.9 | - |
Cys-Gly as substrate | Rattus norvegicus |
| 9.1 | - |
L-alpha-aminobutyryl-Gly as substrate | Rattus norvegicus |
| 11.5 | - |
Leu-p-nitroanilide as substrate | Rattus norvegicus |
| 33.5 | - |
Ala-Gly as substrate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Gly + H2O | - |
Rattus norvegicus | Ala + Gly | - |
? | |
| aminoacyl peptide | - |
Rattus norvegicus | ? | - |
? | |
| Cys-Gly + H2O | - |
Rattus norvegicus | Cys + Gly | - |
? | |
| dipeptides + H2O | not: D-Ala-Gly, Val-Gly, Asp-Gly, Gly-D-Ala, Pro-containing peptides | Rattus norvegicus | amino acids | - |
? | |
| L-alpha-aminobutyryl-Gly + H2O | - |
Rattus norvegicus | L-alpha-aminobutyrate + Gly | - |
? | |
| L-cystinyl-bis-Gly + H2O | - |
Rattus norvegicus | 2 Gly + L-cysteine | - |
? | |
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