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Literature summary for 3.4.11.2 extracted from

  • Gros, C.; Giros, B.; Schwartz, J.C.
    Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes (1985), Biochemistry, 24, 2179-2185.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bestatin Ki: 0.004 mM Rattus norvegicus
EDTA 60-80% inhibition at 20 mM Rattus norvegicus
puromycin Ki: 0.1 mM, low sensitivity to puromycin Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
Leu-2-naphthylamide from brain Rattus norvegicus
0.025
-
L-Arg-2-naphthylamide from kidney Rattus norvegicus
0.027
-
L-Arg-2-naphthylamide from brain Rattus norvegicus
0.027
-
Leu-2-naphthylamide from kidney Rattus norvegicus
0.038
-
Ala-2-naphthylamide from kidney Rattus norvegicus
0.04
-
Ala-2-naphthylamide from brain Rattus norvegicus
0.045
-
Leu5-enkephalin from brain Rattus norvegicus
0.045
-
Met5-enkephalin from brain Rattus norvegicus
0.06
-
Met5-enkephalin from kidney Rattus norvegicus
0.065
-
Leu5-enkephalin from kidney Rattus norvegicus
0.8
-
Gly-2-naphthylamide from brain Rattus norvegicus
1
-
Gly-2-naphthylamide from kidney Rattus norvegicus
2.1 2.9 Phe-Gly
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane cerebral membrane Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ reactivation after inhibition by EDTA Rattus norvegicus
Co2+ reactivation after inhibition by EDTA Rattus norvegicus
Mn2+ reactivation after inhibition by EDTA Rattus norvegicus
Zn2+ reactivation after inhibition by EDTA Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aminoacyl peptide Rattus norvegicus
-
?
-
?
enkephalin Rattus norvegicus may be involved in enkephalin neurotransmitter inactivation ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aminoacyl peptide
-
Rattus norvegicus ?
-
?
aminoacyl-2-naphthylamide + H2O
-
Rattus norvegicus amino acid + 2-naphthylamine
-
?
enkephalin may be involved in enkephalin neurotransmitter inactivation Rattus norvegicus ?
-
?
Gly-2-naphthylamide + H2O
-
Rattus norvegicus Gly + 2-naphthylamine
-
?
L-Arg-2-naphthylamide + H2O
-
Rattus norvegicus L-Arg + 2-naphthylamine
-
?
Leu-2-naphthylamide + H2O
-
Rattus norvegicus Leu + 2-naphthylamine
-
?
Leu5-enkephalin + H2O
-
Rattus norvegicus tyrosin + (2-5)Leu5-enkephalin
-
?
Met5-enkephalin + H2O
-
Rattus norvegicus tyrosin + (2-5)Met5-enkephalin
-
?
Phe-Gly + H2O
-
Rattus norvegicus Phe + Gly
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
bestatin
-
Rattus norvegicus