Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor-diffusion method | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis | |
(2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | - |
Mycobacterium tuberculosis | |
Fe2+ | - |
Mycobacterium tuberculosis | |
Mn2+ | - |
Mycobacterium tuberculosis | |
Ni2+ | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
as apoenzyme which can be activated by Co2+, Mn2+, Ni2+, Fe2+ | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-7-amido-4-methylcoumarin + H2O | - |
Mycobacterium tuberculosis | L-methionine + 7-amino-4-methylcoumarin | - |
? | |
L-methionyl-7-amido-4-methylcoumarin + H2O | - |
Mycobacterium tuberculosis | L-methionine + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine aminopeptidase type 1a | - |
Mycobacterium tuberculosis |
methionine aminopeptidase type 1c | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0004 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.00054 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.00062 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.00076 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.00096 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0013 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0037 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0042 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0045 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0055 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.006 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0067 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0069 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0079 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.0081 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.011 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.011 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.012 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.014 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.018 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.021 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.026 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.031 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.033 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.039 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.045 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.049 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.05 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.052 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.061 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.067 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.068 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.068 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.075 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[2-(mesityloxy)ethyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.08 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(4-fluorophenyl)-3-(furan-2-yl)propyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.088 | - |
apoenyme activated by Co2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.11 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.114 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.12 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2-amino-2-oxoethyl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.14 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.141 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.15 | - |
apoenyme activated by Ni2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[3-(furan-2-yl)-3-phenylpropyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.179 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-3,4,5-trihydroxy-N-[(1-isobutyrylpiperidin-3-yl)-methyl]-2-methoxy-8,8-dimethylnon-6-enamide | |
0.187 | - |
apoenyme activated by Mn2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-[[1-(cyclopropanecarbonyl)piperidin-3-yl]methyl]-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide | |
0.201 | - |
apoenyme activated by Fe2+, pH 7.5, 22°C | Mycobacterium tuberculosis | (2R,3R,4S,5R,E)-N-(2,3-dihydro-1H-inden-2-yl)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide |