Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates, two metal ions are coordinated by five conserved amino acid residues D97, D108, H171, E204 and E235, activation kinetics, overview | Escherichia coli | |
additional information | MetAP belongs to the dinuclear metallohydrolases, mathematical model and detailed analysis of the stoichiometric activation of MetAP by metal cofactors, overview | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MetAP | - |
Escherichia coli |
methionine aminopeptidase | - |
Escherichia coli |
More | MetAP belongs to the dinuclear metallohydrolases | Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | MetAP is a ubiquitous enzyme required for cell survival and an attractive target for antibacterial and anticancer drug development. MetAP is involved in protein maturation by catalyzing the hydrolytic excision of the N-terminal methionine from nascent proteins | Escherichia coli |