Cloned (Comment) | Organism |
---|---|
overexpression in Escherichia coli strain BL21(DE3) | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxy-4-(2-methyl-1,3-thiazol-4-yl)benzamide | - |
Escherichia coli | |
3-(2-methyl-1,3-thiazol-4-yl)phenol | - |
Escherichia coli | |
4-(1,3-thiazol-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(2,5-dichlorothiophen-3-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(2,5-dimethylthiophen-3-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(2-amino-1,3-thiazol-4-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(2-methyl-1,3-thiazol-4-yl)-2-nitroaniline | - |
Escherichia coli | |
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diamine | - |
Escherichia coli | |
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(2-methyl-1,3-thiazol-4-yl)benzene-1,3-diol | - |
Escherichia coli | |
4-(3,4-dimethoxyphenyl)-2-methyl-1,3-thiazole | - |
Escherichia coli | |
4-(3-butylthiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(3-ethylthiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(3-methylthiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(3-propylthiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(4-bromo-2,5-dimethylthiophen-3-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(5-chlorothiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(5-methylthiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(thiophen-2-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-(thiophen-3-yl)benzene-1,2-diol | - |
Escherichia coli | |
4-[3-(2-bromoethyl)thiophen-2-yl]benzene-1,2-diol | - |
Escherichia coli | |
5-(2,5-dichlorophenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(2-chlorophenyl)furan-2-carboxylic acid | - |
Escherichia coli | |
5-(3,4-dihydroxyphenyl)-2-methyl-N-(propan-2-yl)-1,3-thiazole-4-carboxamide | - |
Escherichia coli | |
5-(3,4-dihydroxyphenyl)thiophene-2-carbonitrile | - |
Escherichia coli | |
N-(pyridin-2-ylmethyl)-N'-(1,3-thiazol-2-yl)ethanediamide | - |
Escherichia coli | |
N-cyclopentyl-N'-(1,3-thiazol-2-yl)ethanediamide | - |
Escherichia coli | |
N-cyclopropyl-2-(3,4-dihydroxyphenyl)thiophene-3-carboxamide | - |
Escherichia coli | |
N-cyclopropyl-5-(3,4-dihydroxyphenyl)-2-methyl-1,3-thiazole-4-carboxamide | - |
Escherichia coli | |
N-cyclopropyl-5-(3,4-dihydroxyphenyl)thiophene-2-carboxamide | - |
Escherichia coli | |
N-[4-(2-methyl-1,3-thiazol-4-yl)-2-nitrophenyl]acetamide | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates | Escherichia coli | |
Fe2+ | activates | Escherichia coli | |
Mn2+ | activates | Escherichia coli | |
additional information | MetAp requires divalent metal ions for catalytic activity | Escherichia coli | |
Ni2+ | activates | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionyl 4-methylcoumarin-7-amide + H2O | fluorogenic substrate | Escherichia coli | L-methionine + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP | - |
Escherichia coli |
methionine aminopeptidase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
inhibitor screening, assay method development, and assay validation, overview | Escherichia coli | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | MetAP plays a critical role in protein maturation by catalyzing the removal of the N-terminal initiator methionine from nascent proteins | Escherichia coli |