Application | Comment | Organism |
---|---|---|
drug development | MetAP is a promising target for developing broad spectrum antibacterial agents | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(quinolin-8-yl)methanesulfonamide | a trimetalated enzyme, forms a complex with the enzyme, cuases bacterial growth inhibition of strains AS19, D22 and SM101 by targeting MetAP by recruitment of a third auxiliary metal, binding structure, overview | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates, required for enzyme inhibition by inhibitor 1, overview | Escherichia coli | |
Co2+ | activates, required for enzyme inhibition by inhibitor 1, overview | Escherichia coli | |
Fe2+ | activates, required for enzyme inhibition by inhibitor 1, overview | Escherichia coli | |
Mg2+ | activates, required for enzyme inhibition by inhibitor 1, overview | Escherichia coli | |
Mn2+ | activates, required for enzyme inhibition by inhibitor 1, overview | Escherichia coli | |
additional information | MetAP can be activated in vitro by a number of divalent metals | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
strains AS19, D22 and SM101 | - |
Synonyms | Comment | Organism |
---|---|---|
MetAP | - |
Escherichia coli |
methionine aminopeptidase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 values for N-(quinolin-8-yl)methanesulfonamide with different metal ions, overview | Escherichia coli | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | methionine aminopeptidase plays an essential role for cell survival | Escherichia coli |