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Literature summary for 3.4.11.18 extracted from

  • Priest, R.C.; Spaull, J.; Buckton, J.; Grimley, R.L.; Sims, M.; Binks, M.; Malhotra, R.
    Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation (2009), Clin. Exp. Immunol., 155, 514-522.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed with a baculovirus expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester PPI-2458, potent inhibitor Callithrix jacchus
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester PPI-2458, potent inhibitor Homo sapiens
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester PPI-2458, potent inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Callithrix jacchus
-
 marmoset
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
blood
-
 Callithrix jacchus
-
germinal center
-
 Homo sapiens
-
additional information MetAP-2 is not detected in spleen Mus musculus
-
spleen
-
 Homo sapiens
-
spleen
-
 Callithrix jacchus
-
tonsil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O
-
 Mus musculus L-Met + Gly-L-Trp-L-Met-L-Asp
-
 ?
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O
-
 Homo sapiens L-Met + Gly-L-Trp-L-Met-L-Asp
-
 ?
L-Met-Gly-L-Trp-L-Met-L-Asp + H2O
-
 Callithrix jacchus L-Met + Gly-L-Trp-L-Met-L-Asp
-
 ?

Synonyms

Synonyms Comment Organism
MetAP-2
-
 Mus musculus
MetAP-2
-
 Homo sapiens
MetAP-2
-
 Callithrix jacchus
methionine aminopeptidase-2
-
 Mus musculus
methionine aminopeptidase-2
-
 Homo sapiens
methionine aminopeptidase-2
-
 Callithrix jacchus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000245
-
 [(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiranyl]-1-oxaspiro(2,5)oct-6-yl ester recombinant MetAP-2, in 50 mM Hepes, 100 mM MnCl2, 100 mM NaCl, 0.005% (w/v) bovine serum albumin, 0.006% (w/v) 3-[(3-cholamidopropyl)dimethylammonio]propanesulphonic acid, at pH 7.5 Homo sapiens