Literature summary for 3.4.11.18 extracted from

Wang, J.; Tucker, L.A.; Stavropoulos, J.; Zhang, Q.; Wang, Y.C.; Bukofzer, G.; Niquette, A.; Meulbroek, J.A.; Barnes, D.M.; Shen, J.; Bouska, J.; Donawho, C.; Sheppard, G.S.; Bell, R.L.
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor (2008), Proc. Natl. Acad. Sci. USA, 105, 1838-1843.

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Inhibitors

Inhibitors	Comment	Organism	Structure
A-357300	-	Mus musculus
A-800141	-	Mus musculus
TNP-470	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O08663	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GAPDH + H2O	MetAP2-specific substrate	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
MetAP2	-	Mus musculus
methionine aminopetidase-2	-	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000008	-	MetAP2	Mus musculus	A-800141
0.000012	-	MetAP2	Mus musculus	TNP-470
0.00012	-	MetAP2	Mus musculus	A-357300

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Release 2023.1 (January 2023)