Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3E)-3-(furan-2-ylmethylidene)-5-(hydroxymethyl)-1-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one | no activity at 0.1 mM | Homo sapiens | |
1-methoxy-5-(methoxymethyl)-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one | no activity at 0.1 mM | Homo sapiens | |
2-(5-methoxy-6-[2-methyl-3-((3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hex-1-yl)methyl)-1H-isoindole-1,3(2H)-dione | no activity at 0.1 mM | Homo sapiens | |
5-(hydroxymethyl)-1-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-ol | no activity at 0.1 mM | Homo sapiens | |
5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde | - |
Homo sapiens | |
6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one | - |
Homo sapiens | |
6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one | - |
Homo sapiens | |
ethyl (6E)-8-[(2R,3R)-3-[(1S,5S)-5-(hydroxymethyl)-1-methoxy-2-oxobicyclo[3.1.0]hex-6-yl]-3-methyloxiran-2-yl]oct-6-enoate | no activity at 0.1 mM | Homo sapiens | |
fumagalone | - |
Homo sapiens | |
fumagillin | - |
Homo sapiens | |
fumarranol | selective inhibitor | Homo sapiens | |
TNP-470 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | Homo sapiens | - |
Met + peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50579 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | - |
Homo sapiens | Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP2 | - |
Homo sapiens |
type 2 methionine aminopeptidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
- |
Homo sapiens | TNP-470 | |
0.00323 | - |
- |
Homo sapiens | fumarranol | |
0.008 | - |
- |
Homo sapiens | fumagalone | |
0.0132 | - |
- |
Homo sapiens | 5-methoxy-6-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-oxobicyclo[3.1.0]hexane-1-carbaldehyde | |
0.0338 | - |
- |
Homo sapiens | 6-[(1E)-1,5-dimethylhexa-1,4-dien-1-yl]-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one | |
0.0575 | - |
- |
Homo sapiens | 6-(1,5-dimethylhex-4-en-1-yl)-5-(hydroxymethyl)-1-methoxybicyclo[3.1.0]hexan-2-one |