Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid | - |
Mus musculus | |
2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | - |
Mus musculus | |
2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | - |
Mus musculus | |
2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid | - |
Mus musculus | |
2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | - |
Mus musculus | |
2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid | potent inhibitor but lacks cellular activity and is highly protein bound | Mus musculus | |
3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid | - |
Mus musculus | |
5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | - |
Mus musculus | |
6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid | - |
Mus musculus | |
6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid | - |
Mus musculus | |
6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | Mus musculus | - |
Met + peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O08663 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Met-peptide + H2O | - |
Mus musculus | Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP2 | - |
Mus musculus |
methionine aminopeptidase-2 | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid | |
0.000009 | - |
- |
Mus musculus | 2-[(phenylsulfonyl)amino]-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid | |
0.00001 | - |
- |
Mus musculus | 6-[[(2-[[4-(dimethylamino)butyl]amino]phenyl)sulfonyl]amino]-3-ethyl-2-methoxybenzoic acid | |
0.000011 | - |
- |
Mus musculus | 2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methoxybenzoic acid | |
0.000015 | - |
- |
Mus musculus | 2-chloro-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | |
0.000015 | - |
- |
Mus musculus | 3-ethyl-2-methoxy-6-[[(2-[[2-(1-methylpyrrolidin-2-yl)ethyl]amino]phenyl)sulfonyl]amino]benzoic acid | |
0.000015 | - |
- |
Mus musculus | 6-[[(2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-furan-3-yl-2-methoxybenzoic acid | |
0.000016 | - |
- |
Mus musculus | 2-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | |
0.000016 | - |
- |
Mus musculus | 2-(2-aminoethoxy)-3-ethyl-6-[[(2-propylphenyl)sulfonyl]amino]benzoic acid | |
0.000017 | - |
- |
Mus musculus | 6-[[(2-[[3-(dimethylamino)propyl]amino]-4-fluorophenyl)sulfonyl]amino]-3-furan-3-yl-2-methoxybenzoic acid | |
0.000018 | - |
- |
Mus musculus | 3-ethyl-2-methoxy-6-[[(2-[[3-(2-methylpiperidin-1-yl)propyl]amino]phenyl)sulfonyl]amino]benzoic acid | |
0.00002 | - |
- |
Mus musculus | 6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-3-yl-3-methoxybenzoic acid | |
0.000024 | - |
- |
Mus musculus | 2-(2-aminoethoxy)-6-[([2-[3-(diethylamino)propyl]-4-fluorophenyl]sulfonyl)amino]-3-ethylbenzoic acid | |
0.000026 | - |
- |
Mus musculus | 6-[([2-[(1E)-3-(diethylamino)prop-1-en-1-yl]-4-fluorophenyl]sulfonyl)amino]-3-ethyl-2-methoxybenzoic acid | |
0.000038 | - |
- |
Mus musculus | 2-ethoxy-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | |
0.000046 | - |
- |
Mus musculus | 2-(2-aminoethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | |
0.000055 | - |
- |
Mus musculus | 5-ethyl-2-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | |
0.00006 | - |
- |
Mus musculus | 2-ethenyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | |
0.000067 | - |
- |
Mus musculus | 3-ethyl-2-methyl-6-[(pyridin-2-ylsulfonyl)amino]benzoic acid | |
0.000078 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-2,3-dimethylbenzoic acid | |
0.00015 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-3-methyl-2-propylbenzoic acid | |
0.00028 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-2-methoxy-3-(1H-pyrazol-4-yl)benzoic acid | |
0.001 | - |
- |
Mus musculus | 6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-furan-2-yl-3-methoxybenzoic acid | |
0.0013 | - |
- |
Mus musculus | 2-butyl-6-[[(4-fluorophenyl)sulfonyl]amino]-3-methylbenzoic acid | |
0.0025 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-2-(1-hydroxyethyl)-3-methylbenzoic acid | |
0.0058 | - |
- |
Mus musculus | 2-(carboxymethoxy)-3-ethyl-6-[[(4-fluorophenyl)sulfonyl]amino]benzoic acid | |
0.008 | - |
- |
Mus musculus | 6-[[(4-fluorophenyl)sulfonyl]amino]-2-(hydroxymethyl)-3-methylbenzoic acid | |
0.036 | - |
- |
Mus musculus | 6-[[(2-bromo-4-fluorophenyl)sulfonyl]amino]-2-(1H-imidazol-4-yl)-3-methoxybenzoic acid |