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Literature summary for 3.4.11.18 extracted from

  • Bernier, S.G.; Lazarus, D.D.; Clark, E.; Doyle, B.; Labenski, M.T.; Thompson, C.D.; Westlin, W.F.; Hannig, G.
    A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis (2004), Proc. Natl. Acad. Sci. USA, 101, 10768-10773.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine enzyme inhibitor PPI-2458 inhibits proliferation of human fibroblast-like synviocytes derived from patients with rheumatoid arthritis with a growth inhibitory concentration of 0.04 nM. Growth inhibition is linked to enzyme inhibition Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PPI-2458 irreversible Homo sapiens
TNP-470
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with rheumatoid arthritis
-