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Literature summary for 3.4.11.18 extracted from

  • Leszczyniecka, M.; Bhatia, U.; Cueto, M.; Nirmala, N.R.; Towbin, H.; Vattay, A.; Wang, B.; Zabludoff, S.; Phillips, P.E.
    MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer (2006), Oncogene, 25, 3471-3478.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme expression is increased in 8 out of 12 tumor samples. Reduction of enzyme level by MAP1D shRNa does not result in any difference of proliferation, cell survival, or cell numbers, but cells exhibit a dramatically reduced potential to form colonies in soft agar Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
expressed in Sf21 insect cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
colon cancer cell lines and patiens with colon tumors
-

Purification (Commentary)

Purification (Comment) Organism
glutathione agarose chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
carcinoma cell overexpression in colon cancer cell Homo sapiens
-
colon overexpression in colon cancer cell Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HCT-116 cell and HT-29 cell, highest expression levels found Homo sapiens
-
HT-29 cell and HCT-116 cell, highest expression levels found Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-Ala-Ser + H2O
-
Homo sapiens Met + Ala-Ser
-
?
additional information no activity when using Glu-Ala-Ser and Leu-Ala-Ser peptides as substrates Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MAP1D
-
Homo sapiens
methionine aminopeptidase
-
Homo sapiens