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Literature summary for 3.4.11.18 extracted from

  • Ye, Q.Z.; Xie, S.X.; Huang, M.; Huang, W.J.; Lu, J.P.; Ma, Z.Q.
    Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor (2004), J. Am. Chem. Soc., 126, 13940-13941.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
Mn(II)-form of enzyme, in complex with inhibitor 5-(2-chlorophenyl)-2-furoic acid Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5-(2-(trifluoromethyl)phenyl)-2-furoic acid Co(II)-form of enzyme, 50% inhibition at 0.073 mM, Mn(II)-form, 50% inhibition at 0.000063 mM, Ni-(II)form, 50% inhibition above 200 mM, Fe-(II)form, 50% inhibition at 0.195 mM Escherichia coli
5-(2-chloro-3-methylphenyl)-2-furoic acid Co(II)-form of enzyme, 50% inhibition at 0.069 mM, Mn(II)-form, 50% inhibition at 0.00096 mM, Ni-(II)form, 50% inhibition above 200 mM, Fe-(II)form, 50% inhibition above 200 mM Escherichia coli
5-(2-chlorophenyl)-2-furoic acid Co(II)-form of enzyme, 50% inhibition at 0.154 mM, Mn(II)-form, 50% inhibition at 0.0024 mM, Ni-(II)form, 50% inhibition above 200 mM, Fe-(II)form, 50% inhibition at 0.186 mM Escherichia coli
5-(2-fluorophenyl)-2-furoic acid Co(II)-form of enzyme, 50% inhibition at 0.198 mM, Mn(II)-form, 50% inhibition at 0.014 mM, Ni-(II)form, 50% inhibition above 200 mM, Fe-(II)form, 50% inhibition above 200 mM Escherichia coli
5-(3-chlorophenyl)-2-furoic acid Co(II)-form of enzyme, 50% inhibition at 0.193 mM, Mn(II)-form, 50% inhibition at 0.019 mM, Ni-(II)form, 50% inhibition above 200 mM, Fe-(II)form, 50% inhibition above 200 mM Escherichia coli
N-(pyridin-2-ylmethyl)-N'-1,3-thiazol-2-ylethanediamide Co(II)-form of enzyme, 50% inhibition at 0.000073 mM, Mn(II)-form, 50% inhibition at 0.043 mM, Ni-(II)form, 50% inhibition at 0.002 mM, Fe-(II)form, 50% inhibition at 0.065 mM Escherichia coli
N-cyclopentyl-N'-1,3-thiazol-2-ylethanediamide Co(II)-form of enzyme, 50% inhibition at 0.000067 mM, Mn(II)-form, 50% inhibition at 0.053 mM, Ni-(II)form, 50% inhibition at 0.001 mM, Fe-(II)form, 50% inhibition at 0.046 mM Escherichia coli
N-isobutyl-N'-1,3-thiazol-2-ylethanediamide Co(II)-form of enzyme, 50% inhibition at 0.00028 mM, Mn(II)-form, 50% inhibition at 0.108 mM, Ni-(II)form, 50% inhibition at 0.0034 mM, Fe-(II)form, 50% inhibition at 0.118 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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