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Literature summary for 3.4.11.18 extracted from

  • Chen, L.L.; Li, J.; Li, J.Y.; Luo, Q.L.; Mao, W.F.; Shen, Q.; Nan, F.J.; Ye, Q.Z.
    Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening (2004), Acta Pharmacol. Sin., 25, 907-914.
    View publication on PubMed
Search for more literature for 3.4.11.18

Inhibitors

Inhibitors Comment Organism Structure
2-((1,3-thiazol-2-ylamino)carbonyl)pyridin-3-yl phenylacetate Co(II)-form of enzyme, 50% inhibition at 0.00046 mM Saccharomyces cerevisiae
2-((1H-1,2,4-triazol-5-ylthio)methyl)benzonitrile Co(II)-form of enzyme, 50% inhibition at 0.00066 mM Saccharomyces cerevisiae
4-(((3-((2-methoxyphenoxy)methyl)-1H-1,2,4-triazol-5-yl)sulfanyl)acetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Co(II)-form of enzyme, 50% inhibition at 0.00099 mM Saccharomyces cerevisiae
Co2+ inhibitory above 0.0625 mM, activating below Saccharomyces cerevisiae
N-1,3-thiazol-2-ylpyridine-2-carboxamide Co(II)-form of enzyme, 50% inhibition at 0.0071 mM Saccharomyces cerevisiae
Zn2+ inhibitory above 0.031 mM, activating below Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.24
-
 L-Met-PSI[C(O)S]Gly-L-Phe Co(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae
6.75
-
 L-Met-PSI[C(O)S]Gly-L-Phe Zn(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae
16
-
 L-Met-PSI[C(O)S]Gly-L-Phe Mn(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ inhibitory above 0.0625 mM Saccharomyces cerevisiae
Mn2+
-
 Saccharomyces cerevisiae
additional information not activating: Ni2+, Mg2+, Ca2+, Cd2+, Cu2+ Saccharomyces cerevisiae
Zn2+ inhibitory above 0.031 mM Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 x * 44000, SDS-PAGE Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 type I enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Met-PSI[C(O)S]Gly-L-Phe + H2O
-
 Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
? x * 44000, SDS-PAGE Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6
-
 L-Met-PSI[C(O)S]Gly-L-Phe Co(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae
12.8
-
 L-Met-PSI[C(O)S]Gly-L-Phe Zn(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae
15.8
-
 L-Met-PSI[C(O)S]Gly-L-Phe Mn(II)-form of enzyme, 22°C, pH 7.0 Saccharomyces cerevisiae