Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amastatin | - |
Sus scrofa | |
bestatin | - |
Sus scrofa | |
phosphate | - |
Sus scrofa | |
probestin | - |
Sus scrofa | |
rentiapril | the enzyme has an overlapping substrate specificity and inhibitor profile with the related mammalian membrane-bound zinc aminopeptidases membrane alanyl aminopeptidase (EC 3.4.11.2) and glutamyl aminopeptidase (EC 3.4.11.16), but can be distinguished from them by its inhibition by rentiopril and zofenoprilat | Sus scrofa | |
zofenoprilat | the enzyme has an overlapping substrate specificity and inhibitor profile with the related mammalian membrane-bound zinc aminopeptidases membrane alanyl aminopeptidase (EC 3.4.11.2) and glutamyl aminopeptidase (EC 3.4.11.16), but can be distinguished from them by its inhibition by rentiopril and zofenoprilat | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral membrane protein, microvillar membrane | Sus scrofa | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn | the enzyme contains 1.2 atoms of zinc per subunit | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
130000 | - |
- |
Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | may be involved in neuropeptide metabolism, may play a minor role in the intestinal metabolism of the artificial sweetener aspartame | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Sus scrofa |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Sus scrofa | - |
kidney | proximal tubule | Sus scrofa | - |
neuron | myelinated and unmyelinated neurons of the peripheral nervous system | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Asp-Phe-NH2 + H2O | - |
Sus scrofa | Asp + Phe-NH2 | - |
? | |
Glu-Trp + H2O | - |
Sus scrofa | Glu + Trp | - |
? | |
additional information | may be involved in neuropeptide metabolism, may play a minor role in the intestinal metabolism of the artificial sweetener aspartame | Sus scrofa | ? | - |
? | |
additional information | the enzyme cleaves Leu-/-Trp, it prefers short peptides with an aromatic residue in the P1' position, with Glu-/-Trp being the best substrate. Dipeptides with Trp, Phe or Tr in the P1' position are rapidly hydrolyzed. The requirement in the P1 position is no stringent. Te enzyme does not hydrolyze N-blocked peptides | Sus scrofa | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Sus scrofa |