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Literature summary for 3.4.11.14 extracted from

  • Karsten, S.L.; Sang, T.K.; Gehman, L.T.; Chatterjee, S.; Liu, J.; Lawless, G.M.; Sengupta, S.; Berry, R.W.; Pomakian, J.; Oh, H.S.; Schulz, C.; Hui, K.S.; Wiedau-Pazos, M.; Vinters, H.V.; Binder, L.I.; Geschwind, D.H.; Jackson, G.R.
    A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration (2006), Neuron, 51, 549-560.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus brain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
Homo sapiens
puromycin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography and Superdex-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-p-nitroanilide + H2O
-
Homo sapiens Ala + p-nitroaniline
-
?
Leu-p-nitroanilide + H2O
-
Homo sapiens Leu + p-nitroaniline
-
?
Lys-p-nitroanilide + H2O
-
Homo sapiens Lys + p-nitroaniline
-
?
Met-p-nitroanilide + H2O
-
Homo sapiens Met + p-nitroaniline
-
?
Pro-p-nitroanilide + H2O
-
Homo sapiens Pro + p-nitroaniline
-
?
tau protein + H2O
-
Homo sapiens ?
-
?
Val-p-nitroanilide + H2O
-
Homo sapiens Val + p-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
NPEPPS
-
Homo sapiens
PSA
-
Homo sapiens
puromycin-sensitive aminopeptidase
-
Homo sapiens