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Literature summary for 3.4.11.10 extracted from

  • Maekinen, K.K.; Maekinen, P.L.; Wilkes, S.H.; Bayliss, M.E.; Prescott, J.M.
    Chemical modification of Aeromonas aminopeptidase. Evidence for the involvement of tyrosyl and carboxyl groups in the activity of the enzyme (1982), Eur. J. Biochem., 128, 257-265.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Phenylglyoxal
-
Vibrio proteolyticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019 0.0215 L-leucine 4-nitroanilide native enzyme, buffer dependent Vibrio proteolyticus
0.032
-
L-leucine 4-nitroanilide diethylpyrocarbonate-treated enzyme Vibrio proteolyticus
0.055
-
L-leucine 4-nitroanilide 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide treated enzyme Vibrio proteolyticus
0.06
-
L-leucine 4-nitroanilide nitro-enzyme Vibrio proteolyticus
0.136
-
L-leucine 4-nitroanilide azo-enzyme Vibrio proteolyticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Peptides + H2O Vibrio proteolyticus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Vibrio proteolyticus
-
chemical modifications: nitration, azotization, diethylpyrocarbonate treatment, 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide treatment
-

Reaction

Reaction Comment Organism Reaction ID
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. presence of at least one active Tyr and one carboxyl group demonstrated by chemical modifications of enzyme: nitration, azotization, diethyldirocarbonate treatment, 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide treatment Vibrio proteolyticus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3
-
azo-enzyme Vibrio proteolyticus
17
-
nitro-enzyme Vibrio proteolyticus
20
-
1-ethyl-3(3-dimethylaminopropyl)-carbodiimide treated enzyme Vibrio proteolyticus
80 115 native enzyme, buffer dependent Vibrio proteolyticus
84
-
diethylpyrocarbonate-treated enzyme Vibrio proteolyticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Peptides + H2O
-
Vibrio proteolyticus ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4
-
L-leucine 4-nitroanilide azo-enzyme Vibrio proteolyticus
14.3
-
L-leucine 4-nitroanilide nitro-enzyme Vibrio proteolyticus
42
-
L-leucine 4-nitroanilide 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide treated enzyme Vibrio proteolyticus
50 69 L-leucine 4-nitroanilide native enzyme, buffer dependent Vibrio proteolyticus
55.5
-
L-leucine 4-nitroanilide diethylpyrocarbonate-treated enzyme Vibrio proteolyticus