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Literature summary for 3.4.11.10 extracted from

  • Kettner, C.; Glover, G.I.; Prescott, J.M.
    Kinetics of inhibition of Aeromonas aminopeptidase by leucine methyl ketone derivatives (1974), Arch. Biochem. Biophys., 165, 739-743.
    View publication on PubMed
Search for more literature for 3.4.11.10

Inhibitors

Inhibitors Comment Organism Structure
Leu-bromomethyl ketone reversible, Ki: 200 nM Vibrio proteolyticus
Leu-chloromethyl ketone reversible, Ki: 670 nM; succinimido derivative, reversible, Ki: 0.17 mM Vibrio proteolyticus
Leu-methyl ketone reversible, Ki: 0.018 mM Vibrio proteolyticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 L-leucine 4-nitroanilide
-
 Vibrio proteolyticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Peptides + H2O Vibrio proteolyticus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio proteolyticus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Leu-4-nitroanilide + H2O
-
 Vibrio proteolyticus Leu + 4-nitroaniline
-
 ir
Peptides + H2O
-
 Vibrio proteolyticus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
64
-
 L-leucine 4-nitroanilide
-
 Vibrio proteolyticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 Leu-bromomethyl ketone reversible Vibrio proteolyticus
0.00067
-
 Leu-chloromethyl ketone reversible Vibrio proteolyticus
0.17
-
 Leu-chloromethyl ketone succinimido derivative, reversible Vibrio proteolyticus