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Literature summary for 3.4.11.1 extracted from
- Isolation and characterization of an aminopeptidase from Lactobacillus acidophilus (1984), Biochim. Biophys. Acta, 789, 26-36.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-leucine | - |
Lactobacillus acidophilus |  |
| L-alanine | - |
Lactobacillus acidophilus | |
| L-asparagine | - |
Lactobacillus acidophilus | |
| L-leucine | competitive | Lactobacillus acidophilus | |
| L-Leucyl ethyl ester | - |
Lactobacillus acidophilus | |
| L-lysine | - |
Lactobacillus acidophilus | |
| L-tyrosine | - |
Lactobacillus acidophilus | |
| L-valine | - |
Lactobacillus acidophilus | |
| p-chloromercuribenzoate | - |
Lactobacillus acidophilus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7.2 | - |
L-Leu-Gly | similar value | Lactobacillus acidophilus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Br- | 4 mM, activation | Lactobacillus acidophilus | |
| Cl- | 4 mM, activation | Lactobacillus acidophilus | |
| Co2+ | activation | Lactobacillus acidophilus | |
| Mn2+ | activation | Lactobacillus acidophilus | |
| Ni2+ | activation | Lactobacillus acidophilus | |
| Zn2+ | contains 4 mol of tightly bound Zn2+ | Lactobacillus acidophilus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38400 | - |
4 * 38400, SDS-PAGE | Lactobacillus acidophilus |
| 156000 | - |
gel filtration | Lactobacillus acidophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Lactobacillus acidophilus | oxidized beta chain of insulin | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactobacillus acidophilus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Lactobacillus acidophilus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Lactobacillus acidophilus |
| 4.2 | - |
- |
Lactobacillus acidophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-amino acid-peptide + H2O | fast hydrolysis of hydrophobic amino acids in N-terminal position | Lactobacillus acidophilus | amino acid + peptide | - |
? | |
| L-Leu-Gly + H2O | - |
Lactobacillus acidophilus | L-Leu + Gly | - |
? | |
| Proteins + H2O | oxidized beta chain of insulin | Lactobacillus acidophilus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 38400, SDS-PAGE | Lactobacillus acidophilus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | - |
Lactobacillus acidophilus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 9 | - |
Lactobacillus acidophilus |
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