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Literature summary for 3.4.11.1 extracted from

  • Millership, J.J.; Chappell, C.; Okhuysen, P.C.; Snowden, K.F.
    Characterization of aminopeptidase activity from three species of microsporidia: Encephalitozoon cuniculi, Encephalitozoon hellem, and Vittaforma corneae (2002), J. Parasitol., 88, 843-848.
    View publication on PubMed
Search for more literature for 3.4.11.1

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 86.3% inhibition at 5 mM Encephalitozoon cuniculi
1,10-phenanthroline 87.8% inhibition at 5 mM Encephalitozoon hellem
bestatin 92.5% inhibition at 0.3 mM Encephalitozoon cuniculi
bestatin 87.0% inhibition at 0.3 mM Encephalitozoon hellem
additional information no inhibition by epibestatin, and by E64, chymostatin, leupeptin, and antipain Encephalitozoon cuniculi
additional information no inhibition by epibestatin, and by E64, chymostatin, leupeptin, and antipain Encephalitozoon hellem
nitrobestatin 95.1% inhibition at 0.133 mM Encephalitozoon cuniculi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Encephalitozoon cuniculi 5829
-
cytosol
-
 Encephalitozoon hellem 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metallopeptidase Encephalitozoon cuniculi
additional information metallopeptidase Encephalitozoon hellem

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 native PAGE Encephalitozoon hellem
74000
-
 native PAGE Encephalitozoon cuniculi

Organism

Organism UniProt Comment Textmining
Encephalitozoon cuniculi
-
-
-
Encephalitozoon hellem
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially, preparation of spores and subcellular fractionation Encephalitozoon cuniculi
partially, preparation of spores and subcellular fractionation Encephalitozoon hellem

Source Tissue

Source Tissue Comment Organism Textmining
spore
-
 Encephalitozoon cuniculi
-
spore
-
 Encephalitozoon hellem
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-7-amido-4-methylcoumarin + H2O
-
 Encephalitozoon cuniculi L-Ala + 7-amino-4-methylcoumarin
-
 ?
L-Ala-7-amido-4-methylcoumarin + H2O
-
 Encephalitozoon hellem L-Ala + 7-amino-4-methylcoumarin
-
 ?
L-Arg-7-amido-4-methylcoumarin + H2O
-
 Encephalitozoon cuniculi L-Arg + 7-amino-4-methylcoumarin
-
 ?
L-Arg-7-amido-4-methylcoumarin + H2O
-
 Encephalitozoon hellem L-Arg + 7-amino-4-methylcoumarin
-
 ?
L-Leu-7-amido-4-methylcoumarin + H2O best substrate Encephalitozoon cuniculi L-Leu + 7-amino-4-methylcoumarin
-
 ?
L-Leu-7-amido-4-methylcoumarin + H2O best substrate Encephalitozoon hellem L-Leu + 7-amino-4-methylcoumarin
-
 ?
L-Met-7-amido-4-methylcoumarin + H2O no activity with Z-Met-7-amido-4-methylcoumarin Encephalitozoon cuniculi L-Met + 7-amino-4-methylcoumarin
-
 ?
L-Met-7-amido-4-methylcoumarin + H2O no activity with Z-Met-7-amido-4-methylcoumarin Encephalitozoon hellem L-Met + 7-amino-4-methylcoumarin
-
 ?
L-Phe-7-amido-4-methylcoumarin + H2O low activity Encephalitozoon cuniculi L-Phe + 7-amino-4-methylcoumarin
-
 ?
L-Phe-7-amido-4-methylcoumarin + H2O low activity Encephalitozoon hellem L-Phe + 7-amino-4-methylcoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Encephalitozoon cuniculi
37
-
 assay at Encephalitozoon hellem