Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for the antimalarial activity of inhibitor bestatin | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, overexpression of the full-length gene in parasite cytosol, transgenic parasites are more resistant to bestatin | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | - |
Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Plasmodium falciparum | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
x * 65000, recombinant enzyme, SDS-PAGE, x * 67831, sequence calculation | Plasmodium falciparum |
67831 | - |
x * 65000, recombinant enzyme, SDS-PAGE, x * 67831, sequence calculation | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Plasmodium falciparum | the enzyme is important in the generation and regulation of free amino acids that are used in protein anabolism and for maintaining osmotic stability within the infected erythrocyte, enzyme inhibition, e.g. by bestatin, blocks intraerythrocytic development of malaria parasites | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
clone D10 of isolate FC27 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alanyl-7-amido-4-methylcoumarin + H2O | - |
Plasmodium falciparum | alanine + 7-amino-4-methylcoumarin | - |
? | |
L-leucyl-7-amido-4-methylcoumarin + H2O | - |
Plasmodium falciparum | L-leucine + 7-amino-4-methylcoumarin | - |
? | |
additional information | the enzyme is important in the generation and regulation of free amino acids that are used in protein anabolism and for maintaining osmotic stability within the infected erythrocyte, enzyme inhibition, e.g. by bestatin, blocks intraerythrocytic development of malaria parasites | Plasmodium falciparum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, recombinant enzyme, SDS-PAGE, x * 67831, sequence calculation | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family M17 | Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Plasmodium falciparum |