Protein Variants | Comment | Organism |
---|---|---|
K528A | gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity | Homo sapiens |
K528H | gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity | Homo sapiens |
K528M | gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity | Homo sapiens |
K528R | gene A-LAP, natural polymorphism and site-directed mutagenesis, hypertension-associated mutant, the mutant enzyme shows reduced activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme inhibition causes hypertension | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low | Lys528 is located near the entrance of the substrate pocket and is important for maximal activity by maintaining the appropriate structure of the substrate binding pocket | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme inhibition causes hypertension | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-LAP | - |
Homo sapiens |
adipocyte-derived leucine aminopeptidase | - |
Homo sapiens |
ER-aminopeptidase-1 | - |
Homo sapiens |
More | the multifunctional enzyme belongs to the M1 aminopeptidase family | Homo sapiens |