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Literature summary for 3.4.11.1 extracted from

  • Goto, Y.; Hattori, A.; Ishii, Y.; Tsujimoto, M.
    Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 (2006), FEBS Lett., 580, 1833-1838.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K528A gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity Homo sapiens
K528H gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity Homo sapiens
K528M gene A-LAP, site-directed mutagenesis, the mutant enzyme shows reduced activity Homo sapiens
K528R gene A-LAP, natural polymorphism and site-directed mutagenesis, hypertension-associated mutant, the mutant enzyme shows reduced activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme inhibition causes hypertension ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low Lys528 is located near the entrance of the substrate pocket and is important for maximal activity by maintaining the appropriate structure of the substrate binding pocket Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme inhibition causes hypertension Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
A-LAP
-
Homo sapiens
adipocyte-derived leucine aminopeptidase
-
Homo sapiens
ER-aminopeptidase-1
-
Homo sapiens
More the multifunctional enzyme belongs to the M1 aminopeptidase family Homo sapiens