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Literature summary for 3.4.11.1 extracted from
- Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver (2003), Biol. Chem., 384, 213-218.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bestatin | - |
Rattus norvegicus |  |
| o-phenanthroline | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| ZnCl2 | activating | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cysteinylglycine + H2O | Rattus norvegicus | involved in the metabolism of glutathione and glutathione S-conjugates, major cysteinylglycine-hydrolysing activity | cysteine + glycine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0007 | - |
purified enzyme, substrate leukotriene D4 | Rattus norvegicus |
| 0.021 | - |
cytosolic fraction, substrate bimane-S-cysteinylglycine | Rattus norvegicus |
| 0.184 | - |
cytosolic fraction, substrate cysteinylglycine | Rattus norvegicus |
| 1.1 | - |
purified enzyme, substrate bimane-S-cysteinylglycine | Rattus norvegicus |
| 9.5 | - |
purified enzyme, substrate cysteinylglycine | Rattus norvegicus |
| 14 | - |
purified enzyme, substrate cysteinyl-bis-glycine | Rattus norvegicus |
| 52 | - |
purified enzyme, substrate S-nitrosocysteinylglycine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bimane-S-cysteinylglycine + H2O | - |
Rattus norvegicus | ? | - |
? | |
| cysteinyl-bis-glycine + H2O | - |
Rattus norvegicus | cysteine + glycine | - |
? | |
| cysteinylglycine + H2O | - |
Rattus norvegicus | cysteine + glycine | - |
? | |
| cysteinylglycine + H2O | involved in the metabolism of glutathione and glutathione S-conjugates, major cysteinylglycine-hydrolysing activity | Rattus norvegicus | cysteine + glycine | - |
? | |
| leukotriene D4 + H2O | low activity | Rattus norvegicus | ? | - |
? | |
| S-nitrosocysteinylglycine + H2O | - |
Rattus norvegicus | S-nitrosocysteine + glycine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cysteinylglycine-hydrolysing activity | - |
Rattus norvegicus |
| LAP | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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