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Literature summary for 3.3.2.6 extracted from
- Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase (2009), Curr. Opin. Investig. Drugs, 10, 1173-1182.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of LTB4 synthesis may be beneficial in the treatment of severe asthma and viral exacerbations of asthma, in which neutrophilic inflammation is more prominent | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a single-nucleotide polymorphism and a particular haplotype for the LTA4H gene are linked to an increased risk for the development of asthma, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (4S)-4-amino-5-hydroxy-N-(4-phenoxyphenyl)pentanamide | - |
Homo sapiens |  |
| (4S)-4-[(4-tert-butylbenzyl)sulfanyl]-1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline | - |
Homo sapiens | |
| 1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid | JNJ-27265732 | Homo sapiens | |
| 4-([(2R)-2-[(methyl[2-oxo-2-[(4-phenoxyphenyl)amino]ethyl]amino)methyl]pyrrolidin-1-yl]methyl)benzoic acid | - |
Homo sapiens | |
| 4-[(2R)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]pyrrolidin-1-yl]butanoic acid | - |
Homo sapiens | |
| 4-[[(1R,5S)-3-([4-[3-(1,3-oxazol-2-yl)phenoxy]phenyl]amino)-8-azabicyclo[3.2.1]oct-8-yl]methyl]benzoic acid | JNJ-26993135 | Homo sapiens | |
| DG-051 | a LTA4H inhibitor, used for therapeutic modulation of the leukotriene synthesis pathway in case of myocardial infarction | Homo sapiens | |
| N-[1-[4-(1,3-benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide | SC-57461A | Homo sapiens | |
| N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine | SA-6541 | Homo sapiens | |
| S-(4-cyclohexylbenzyl)-N-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-cysteine | - |
Homo sapiens | |
| SC-57461A | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | Mus musculus | - |
leukotriene B4 | - |
? | |
| leukotriene A4 + H2O | Homo sapiens | - |
leukotriene B4 | - |
? | |
| leukotriene A4 + H2O | Mus musculus C57BL/6 | - |
leukotriene B4 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | - |
Mus musculus | leukotriene B4 | - |
? | |
| leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
| leukotriene A4 + H2O | - |
Mus musculus C57BL/6 | leukotriene B4 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene A4 hydrolase | - |
Mus musculus |
| leukotriene A4 hydrolase | - |
Homo sapiens |
| LTA4H | - |
Mus musculus |
| LTA4H | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the enzyme is linked to inflammation diseases, especially asthma and also rheumatoid arthritis, significant role for LTB4 production in the pathogenesis of asthma, overview. LTB4 and BLT1 may be involved in the steroid resistance experienced by some patients with asthma | Homo sapiens |
| malfunction | the enzyme is linked to inflammation diseases, especially asthma and rheumatoid arthritis , mouse model, overview | Mus musculus |
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