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Literature summary for 3.3.2.6 extracted from

  • Via, M.; De Giacomo, A.; Corvol, H.; Eng, C.; Seibold, M.A.; Gillett, C.; Galanter, J.; Sen, S.; Tcheurekdjian, H.; Chapela, R.; Rodriguez-Santana, J.R.; Rodriguez-Cintron, W.; Thyne, S.; Avila, P.C.; Choudhry, S.; Gonzalez Burchard, E.; Gonzalez Burchard, E.
    The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos (2010), Clin. Exp. Allergy, 40, 582-589.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics LTA4H genes are risk factors for asthma in two different ethnic groups, individuals from Mexico and Puerto Rico Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
LTA4H gene, genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information two single-nucleotide polymorphisms within the LTA4H gene, rs17525488 and rs2540493, are protective against asthma in individuals from Mexico and Puerto Rico. Among the Mexican patients, LTA4H polymorphisms are associated with baseline lung function and IgE levels. Identification of a gene-gene interaction between LTA4H, rs17525488, and arachidonate 5-lipoxygenase-activating protein gene ALOX5AP, rs1050739 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
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Homo sapiens
LTA4H
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Homo sapiens

General Information

General Information Comment Organism
malfunction LTA4H polymorphisms are involved in pathogenesis of asthma Homo sapiens