Literature summary for 3.3.2.6 extracted from

Qiu, H.; Gabrielsen, A.; Agardh, H.E.; Wan, M.; Wetterholm, A.; Wong, C.H.; Hedin, U.; Swedenborg, J.; Hansson, G.K.; Samuelsson, B.; Paulsson-Berne, G.; Haeggstroem, J.Z.
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability (2006), Proc. Natl. Acad. Sci. USA, 103, 8161-8166.

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Application

Application	Comment	Organism
medicine	LTA4H appears to be a promising target for development of drugs for prevention and treatment of atherosclerosis and its associated thrombotic complications	Mus musculus
medicine	LTA4H appears to be a promising target for development of drugs for prevention and treatment of atherosclerosis and its associated thrombotic complications	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
aminohydroxamic acid	-	Homo sapiens
aminohydroxamic acid	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O	Mus musculus	-	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate	-	?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O	Homo sapiens	-	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	aortic lesion	Mus musculus	-
aorta	aortic lesion	Homo sapiens	-
atherosclerotic carotid plaque	carotid atherosclerotic lesion	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O	-	Mus musculus	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate	-	?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O	-	Homo sapiens	(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
leukotriene-A4 hydrolase	-	Mus musculus
leukotriene-A4 hydrolase	-	Homo sapiens
LTA4H	-	Mus musculus
LTA4H	-	Homo sapiens

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Release 2023.1 (January 2023)