Literature summary for 3.3.2.6 extracted from

Chen, X.; Li, N.; Wang, S.; Wu, N.; Hong, J.; Jiao, X.; Krasna, M.J.; Beer, D.G.; Yang, C.S.
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin (2003), J. Natl. Cancer Inst., 95, 1053-1061.

Search for more literature for 3.3.2.6

Application

Application	Comment	Organism
medicine	enzyme overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of esophageal adenocarcinogenesis	Homo sapiens
medicine	enzyme overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of esophageal adenocarcinogenesis	Rattus norvegicus
medicine	the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4	Homo sapiens
medicine	the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
bestatin	-	Homo sapiens
bestatin	bestatin inhibits leukotriene B4 biosynthesis in the esophageal tissues	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
leukotriene A4 + H2O	Homo sapiens	biosynthesis of leukotriene B4	leukotriene B4	-	?
leukotriene A4 + H2O	Rattus norvegicus	biosynthesis of leukotriene B4	leukotriene B4	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	P30349	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	-	Homo sapiens	-
endothelial cell	-	Homo sapiens	-
epithelium	esophageal and duodenal	Homo sapiens	-
epithelium	esophageal and duodenal	Rattus norvegicus	-
esophagus	basal cells	Homo sapiens	-
esophagus	basal cells	Rattus norvegicus	-
fibroblast	-	Homo sapiens	-
liver	-	Homo sapiens	-
additional information	esophageal adenocarcinoma tumor	Homo sapiens	-
additional information	esophageal adenocarcinoma tumor	Rattus norvegicus	-
additional information	enzyme is higher in columnar-lined esophagus, dysplastic, and total esophageal adenocarcinoma tissues than in basal cells of esophageal epithelium, however enzyme is expressed in the parabasal cells of esophageal squamous epithelium, enzyme is also overexpressed in other cancers, including colon and lung cancers	Homo sapiens	-
additional information	esophageal aquamous epithelial cells do not express enzyme, even in the presence of reflux esophagitis	Rattus norvegicus	-
muscle	-	Homo sapiens	-
neuron	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
leukotriene A4 + H2O	-	Homo sapiens	leukotriene B4	-	?
leukotriene A4 + H2O	-	Rattus norvegicus	leukotriene B4	-	?
leukotriene A4 + H2O	biosynthesis of leukotriene B4	Homo sapiens	leukotriene B4	-	?
leukotriene A4 + H2O	biosynthesis of leukotriene B4	Rattus norvegicus	leukotriene B4	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)