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Literature summary for 3.3.2.6 extracted from

  • Jendraschak, E.; Kaminski, W.E.; Kiefl, R.; von Schacky, C.
    The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms (1996), Biochem. J., 314, 733-737.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
identification of two isoforms of the mRNA, short and long, by using a sequential reverse transcriptase (RT)-PCR mapping approach, both enzyme mRNAs are expressed in blood cells, endothelial cells, smooth muscle cells, fibroblasts and tumor cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
additional information the short- and long-form mRNA expression levels of selected number of cell types is analysed by quantitative RT-PCR Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc the sequence that codes for the zinc-ion-binding motif is identical in the short-from and long-form enzyme mRNAs Homo sapiens
Zinc zinc protein Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
novel short-form mRNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09960
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens short-form enzyme
-
5.24
Homo sapiens long-form enzyme
-
5.76