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Literature summary for 3.3.2.6 extracted from

  • Haeggstrom, J.Z.; Kull, F.; Rudberg, P.C.; Tholander, F.; Thunnissen, M.M.
    Leukotriene A4 hydrolase (2002), Prostaglandins, 68-69, 495-510.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
albumin stimulates aminopeptidase activity Cavia porcellus
albumin stimulates aminopeptidase activity Mus musculus
albumin stimulates aminopeptidase activity Homo sapiens
albumin stimulates aminopeptidase activity Rattus norvegicus
Br- stimulates aminopeptidase activity Cavia porcellus
Br- stimulates aminopeptidase activity Mus musculus
Br- stimulates aminopeptidase activity Homo sapiens
Br- stimulates aminopeptidase activity Rattus norvegicus
Cl- stimulates aminopeptidase activity Cavia porcellus
Cl- stimulates aminopeptidase activity Mus musculus
Cl- stimulates aminopeptidase activity Homo sapiens
Cl- stimulates aminopeptidase activity Rattus norvegicus
leukotriene A4
-
Saccharomyces cerevisiae
SCN- stimulates aminopeptidase activity Cavia porcellus
SCN- stimulates aminopeptidase activity Mus musculus
SCN- stimulates aminopeptidase activity Homo sapiens
SCN- stimulates aminopeptidase activity Rattus norvegicus

Application

Application Comment Organism
medicine the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock Cavia porcellus
medicine the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock Mus musculus
medicine the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock Homo sapiens
medicine the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock Rattus norvegicus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Mus musculus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of enzyme complexed with bestatin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-oxo-3-amino carboxylic esters
-
Cavia porcellus
2-oxo-3-amino carboxylic esters
-
Homo sapiens
2-oxo-3-amino carboxylic esters
-
Mus musculus
2-oxo-3-amino carboxylic esters
-
Rattus norvegicus
2-oxo-3-amino carboxylic esters
-
Saccharomyces cerevisiae
2-[4-[4-[2-[1-pyrrolidinyl]ethoxy]phenoxy]phenyl]-oxazole
-
Homo sapiens
bestatin
-
Cavia porcellus
bestatin
-
Homo sapiens
bestatin
-
Mus musculus
bestatin
-
Rattus norvegicus
bestatin
-
Saccharomyces cerevisiae
bestatin
-
Xenopus laevis
captopril
-
Cavia porcellus
captopril
-
Homo sapiens
captopril
-
Mus musculus
captopril
-
Rattus norvegicus
captopril
-
Saccharomyces cerevisiae
Kelatorphan
-
Cavia porcellus
Kelatorphan
-
Homo sapiens
Kelatorphan
-
Mus musculus
Kelatorphan
-
Rattus norvegicus
Kelatorphan
-
Saccharomyces cerevisiae
leukotriene A4
-
Cavia porcellus
leukotriene A4
-
Homo sapiens
leukotriene A4
-
Mus musculus
leukotriene A4
-
Rattus norvegicus
methyl-N-[3-[4-(phenylmethyl)-phenoxy]propyl]-beta-alanine
-
Homo sapiens
thioamine
-
Cavia porcellus
thioamine
-
Homo sapiens
thioamine
-
Mus musculus
thioamine
-
Rattus norvegicus
thioamine
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information
-
Homo sapiens
-
-
additional information
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 Cavia porcellus
Zinc catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 Mus musculus
Zinc catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 Homo sapiens
Zinc catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 Rattus norvegicus
Zinc zinc content: 1 mol of zinc per mol of enzyme Mus musculus
Zinc zinc content: 1 mol of zinc per mol of enzyme Homo sapiens
Zinc zinc protein Cavia porcellus
Zinc zinc protein Mus musculus
Zinc zinc protein Homo sapiens
Zinc zinc protein Saccharomyces cerevisiae
Zinc zinc protein Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?
leukotriene A4 + H2O Rattus norvegicus biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Xenopus laevis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene A4 + H2O = leukotriene B4 His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity Cavia porcellus
leukotriene A4 + H2O = leukotriene B4 His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity Mus musculus
leukotriene A4 + H2O = leukotriene B4 His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity Homo sapiens
leukotriene A4 + H2O = leukotriene B4 His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity Rattus norvegicus
leukotriene A4 + H2O = leukotriene B4 mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity Cavia porcellus
leukotriene A4 + H2O = leukotriene B4 mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity Mus musculus
leukotriene A4 + H2O = leukotriene B4 mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity Homo sapiens
leukotriene A4 + H2O = leukotriene B4 mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity Rattus norvegicus
leukotriene A4 + H2O = leukotriene B4 mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity Saccharomyces cerevisiae
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Cavia porcellus
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Mus musculus
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Rattus norvegicus
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Saccharomyces cerevisiae
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Saccharomyces cerevisiae leukotriene B4
-
?
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Xenopus laevis leukotriene B4
-
?
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Cavia porcellus leukotriene B4 mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% ?
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Mus musculus leukotriene B4 mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% ?
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Homo sapiens leukotriene B4 mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% ?
leukotriene A4 + H2O model for the binding of leukotriene A4 to the active site Rattus norvegicus leukotriene B4 mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% ?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Rattus norvegicus leukotriene B4
-
?
additional information
-
Saccharomyces cerevisiae ?
-
?
additional information
-
Xenopus laevis ?
-
?
additional information the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg Cavia porcellus ?
-
?
additional information the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg Mus musculus ?
-
?
additional information the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg Homo sapiens ?
-
?
additional information the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg Rattus norvegicus ?
-
?