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Literature summary for 3.3.2.6 extracted from

  • Haeggström, J.Z.; Wetterholm, A.; Vallee, B.L.; Samuelsson, B.
    Leukotriene A4 hydrolase: an epoxide hydrolase with peptidase activity (1990), Biochem. Biophys. Res. Commun., 173, 431-437.
    View publication on PubMed
Search for more literature for 3.3.2.6

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ apoenzyme can be restored by addition of Co2+, peptidase activity exceeds that of enzyme reactivated with zinc Homo sapiens
Zinc zinc protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?
additional information
-
 Homo sapiens ?
-
 ?