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Literature summary for 3.3.2.6 extracted from

  • Minami, M.; Ohishi, N.; Mutho, H.; Izumi, T.; Bito, H.; Wada, H.; Seyama, Y.; Toh, H.; Shimizu, T.
    Leukotriene A4 hydrolase is a zinc-containing aminopeptidase (1990), Biochem. Biophys. Res. Commun., 173, 620-626.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
Leu-thiol
-
Homo sapiens
PCMB
-
Cavia porcellus
PCMB
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc recombinant enzyme: 0.7-1 mol of zinc/mol of enzyme Homo sapiens
Zinc small intestine: 0.99 mol of zinc/mol of enzyme Cavia porcellus
Zinc zinc protein Cavia porcellus
Zinc zinc protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Cavia porcellus
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Cavia porcellus leukotriene B4
-
?
leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?
additional information
-
Cavia porcellus ?
-
?
additional information
-
Homo sapiens ?
-
?