Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for inhibition of the 6-oxo-cholestan-3beta,5alpha-diol (OCDO) biosynthesis in cancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-oxo-cholestan-3beta,5alpha-diol | OCDO, inhibition of the ChEH activity by OCDO, at higher concentration OCDO is reported to inhibit cholesterol biosynthesis from mevalonate but not from acetate at the D8D7I step (the catalytic subunit of ChEH), leading to the accumulation of Delta-8 sterols. Identification of OCDO as an oncometabolite in humans | Homo sapiens | |
dendrogenin A | DDA | Homo sapiens | |
tamoxifen | - |
Homo sapiens | |
tesmilifene | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | - |
5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
breast cancer cell | enzyme ChEH is upregulated | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
additional information | ChEH is expressed in most mammalian cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ChEH | - |
Homo sapiens |
cholesterol epoxide hydrolase | - |
Homo sapiens |
cholesterol-5,6-epoxide hydrolase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme ChEH is upregulated in breast cancer compared to healthy breast tissue | up |
General Information | Comment | Organism |
---|---|---|
metabolism | cholesterol-5,6-epoxide pathway in normal breast and breast cancers, overview | Homo sapiens |
physiological function | in breast tumors from patients, OCDO production as well as the expression of the enzymes involved in the pathway producing 6-oxo-cholestan-3beta,5alpha-diol (OCDO), namely ChEH subunits and 11beta-hydroxysteroid dehydrogenase of type 2 (HSD2), are higher compared to normal tissues, and overexpression of these enzymes correlates with a higher risk of patient death, indicating that this onco-metabolism is of major importance to breast cancer pathology. The ChEH product 5alpha-cholestane-3beta,5alpha,6beta-triol is metabolized into OCDO | Homo sapiens |