Application | Comment | Organism |
---|---|---|
medicine | in breast cancer tissue, cholesterol epoxide hydrolase ChEH metabolizes cholesterol-5,6-epoxide into cholestane-3beta,5alpha,6beta-triol, which is transformed into the oncometabolite 6-oxo-cholestan-3beta,5alpha-diol by 11beta-hydroxysteroid-dehydrogenase 11betaHSD2. ChEH inhibition and 11betaHSD2 silencing inhibit 6-oxo-cholestan-3beta,5alpha-diol production and tumor growth. Patient breast cancer samples show significantly increased 6-oxocholestan-3beta,5alpha-diol levels and greater ChEH and 11betaHSD2 protein expression compared with normal tissues, and 11betaHSD2 and ChEH overexpression correlate with a higher risk of patient death | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine | - |
Homo sapiens | |
4-hydroxytamoxifen | - |
Homo sapiens | |
clomiphene | - |
Homo sapiens | |
dendrogenin A | - |
Homo sapiens | |
raloxifene | - |
Homo sapiens | |
rimcazole | - |
Homo sapiens | |
tamoxifen | - |
Homo sapiens | |
tesmilifene | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | cholestane-3beta,5alpha,6beta-triol | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | clomiphene | |
0.000064 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | clomiphene | |
0.000065 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-hydroxytamoxifen | |
0.000069 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | raloxifene | |
0.00007 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | tamoxifen | |
0.000095 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-hydroxytamoxifen | |
0.0001 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | raloxifene | |
0.00011 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | tamoxifen | |
0.000172 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | tesmilifene | |
0.00021 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | tesmilifene | |
0.000231 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine | |
0.00025 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-pyrrolidine | |
0.000313 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | dendrogenin A | |
0.00035 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | dendrogenin A | |
0.003 | - |
MCF-7 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | rimcazole | |
0.0035 | - |
MDA-MB231 cells, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | rimcazole |