Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol | - |
Rattus norvegicus | |
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone | - |
Rattus norvegicus | |
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone | - |
Rattus norvegicus | |
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine | - |
Rattus norvegicus | |
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine | - |
Rattus norvegicus | |
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine | - |
Rattus norvegicus | |
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine | - |
Rattus norvegicus | |
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone | - |
Rattus norvegicus | |
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine | - |
Rattus norvegicus | |
2-(4-benzylphenoxy)-N,N-diethylethanamine | - |
Rattus norvegicus | |
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol | - |
Rattus norvegicus | |
2-(diethylamino)ethyl 2,2-diphenylpentanoate | - |
Rattus norvegicus | |
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine | - |
Rattus norvegicus | |
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one | - |
Rattus norvegicus | |
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine | - |
Rattus norvegicus | |
4-(2-(4-benzylphenoxy)ethyl)morpholine | - |
Rattus norvegicus | |
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one | - |
Rattus norvegicus | |
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol | - |
Rattus norvegicus | |
6-oxo-5-alpha-hydroxycholestanol | - |
Rattus norvegicus | |
6-oxocholestanol | - |
Rattus norvegicus | |
7-oxocholestanol | - |
Rattus norvegicus | |
7-oxocholesterol | - |
Rattus norvegicus | |
7alpha-hydroxycholesterol | - |
Rattus norvegicus | |
7beta-hydroxycholesterol | - |
Rattus norvegicus | |
AC-915 | - |
Rattus norvegicus | |
alpha-linolenic acid | - |
Rattus norvegicus | |
amiodarone | - |
Rattus norvegicus | |
arachidonic acid | - |
Rattus norvegicus | |
cholestane-3beta,5alpha,6beta-triol | - |
Rattus norvegicus | |
docosahexaenoic acid | - |
Rattus norvegicus | |
ibogaine | - |
Rattus norvegicus | |
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine | - |
Rattus norvegicus | |
oleic acid | - |
Rattus norvegicus | |
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone | - |
Rattus norvegicus | |
rimcazole | - |
Rattus norvegicus | |
tamoxifen | 0.01 mM, competitive | Rattus norvegicus | |
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane | - |
Rattus norvegicus | |
trifluoroperazine | - |
Rattus norvegicus | |
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0074 | - |
5,6alpha-epoxy-5alpha-cholestan-3beta-ol | pH 7.4, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Rattus norvegicus | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O | - |
Rattus norvegicus | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ChEH | - |
Homo sapiens |
ChEH | - |
Rattus norvegicus |
cholesterol-5,6-epoxide hydrolase | - |
Homo sapiens |
cholesterol-5,6-epoxide hydrolase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine | pH 7.4, 37°C | Rattus norvegicus | |
0.000009 | - |
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine | pH 7.4, 37°C | Rattus norvegicus | |
0.000018 | - |
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine | pH 7.4, 37°C | Rattus norvegicus | |
0.000027 | - |
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine | pH 7.4, 37°C | Rattus norvegicus | |
0.000027 | - |
4-(2-(4-benzylphenoxy)ethyl)morpholine | pH 7.4, 37°C | Rattus norvegicus | |
0.000034 | - |
tamoxifen | pH 7.4, 37°C | Rattus norvegicus | |
0.000035 | - |
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine | pH 7.4, 37°C | Rattus norvegicus | |
0.000036 | - |
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone | pH 7.4, 37°C | Rattus norvegicus | |
0.000039 | - |
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol | pH 7.4, 37°C | Rattus norvegicus | |
0.000057 | - |
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine | pH 7.4, 37°C | Rattus norvegicus | |
0.000062 | - |
2-(4-benzylphenoxy)-N,N-diethylethanamine | pH 7.4, 37°C | Rattus norvegicus | |
0.000089 | - |
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone | pH 7.4, 37°C | Rattus norvegicus | |
0.00009 | - |
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one | pH 7.4, 37°C | Rattus norvegicus | |
0.000099 | - |
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine | pH 7.4, 37°C | Rattus norvegicus | |
0.000135 | - |
trifluoroperazine | pH 7.4, 37°C | Rattus norvegicus | |
0.000145 | - |
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol | pH 7.4, 37°C | Rattus norvegicus | |
0.000155 | - |
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol | pH 7.4, 37°C | Rattus norvegicus | |
0.000203 | - |
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone | pH 7.4, 37°C | Rattus norvegicus | |
0.000241 | - |
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone | pH 7.4, 37°C | Rattus norvegicus | |
0.000649 | - |
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane | pH 7.4, 37°C | Rattus norvegicus | |
0.000733 | - |
amiodarone | pH 7.4, 37°C | Rattus norvegicus | |
0.000864 | - |
7-oxocholestanol | pH 7.4, 37°C | Rattus norvegicus | |
0.000902 | - |
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone | pH 7.4, 37°C | Rattus norvegicus | |
0.0019 | - |
2-(diethylamino)ethyl 2,2-diphenylpentanoate | pH 7.4, 37°C | Rattus norvegicus | |
0.002 | - |
ibogaine | pH 7.4, 37°C | Rattus norvegicus | |
0.0023 | - |
6-oxocholestanol | pH 7.4, 37°C | Rattus norvegicus | |
0.0023 | - |
rimcazole | pH 7.4, 37°C | Rattus norvegicus | |
0.0035 | - |
AC-915 | pH 7.4, 37°C | Rattus norvegicus | |
0.0042 | - |
7-oxocholesterol | pH 7.4, 37°C | Rattus norvegicus | |
0.0061 | - |
7alpha-hydroxycholesterol | pH 7.4, 37°C | Rattus norvegicus | |
0.0069 | - |
7beta-hydroxycholesterol | pH 7.4, 37°C | Rattus norvegicus | |
0.0085 | - |
6-oxo-5-alpha-hydroxycholestanol | pH 7.4, 37°C | Rattus norvegicus | |
0.0091 | - |
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine | pH 7.4, 37°C | Rattus norvegicus | |
0.0097 | - |
cholestane-3beta,5alpha,6beta-triol | pH 7.4, 37°C | Rattus norvegicus | |
0.012 | - |
docosahexaenoic acid | pH 7.4, 37°C | Rattus norvegicus | |
0.018 | - |
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one | pH 7.4, 37°C | Rattus norvegicus | |
0.024 | - |
arachidonic acid | pH 7.4, 37°C | Rattus norvegicus | |
0.0363 | - |
alpha-linolenic acid | pH 7.4, 37°C | Rattus norvegicus | |
0.054 | - |
oleic acid | pH 7.4, 37°C | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of D8D7I (3beta-hydroxysterol-DELTA8-DELTA7-isomerase) and DHCR7 (3beta-hydroxysterol-DELTA7-reductase) abolishes ChEH activity. D8D7I and DHCR7 cooperate in the ChEH activity | Homo sapiens |
physiological function | the existence of ChEH activity in MCF-7 cells, and thus ChEH inhibition and accumulation are likely to play a role in the mechanism of induction of breast cancer cell differentiation and apoptosis by antiestrogen binding site (AEBS) ligands that require sterol autoxidation products | Homo sapiens |