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Literature summary for 3.3.2.10 extracted from
- Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia (2009), J. Cereb. Blood Flow Metab., 29, 1475-1481.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of sEH knockout mice, that show no sex differences in cerebral blood flow and ischemic damage in contrast to wild-type female and male mice | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P34914 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Mus musculus | - |
| blood vessel | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| additional information | cerebrovascular expression and activity of sEH and plasma 14,15-dihydroxyeicosatrienoic acid content are lower in wild-type female than male mice, overview | Mus musculus | - |
| telencephalon | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
sEH activities in male, female, and ovariectomized female wild-type and sEH knockout mice | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | sEH is suppressed by estrogen | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | blood flow during middle cerebral artery occlusion is higher and infarct size is smaller in wild-type female compared with male mice, overview. Sex differences in cerebral blood flow and ischemic damage are abolished after ovariectomy and are absent in sEH knockout mice | Mus musculus |
| metabolism | soluble epoxide hydrolase is a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids, EETs | Mus musculus |
| physiological function | soluble epoxide hydrolase is a key enzyme in the metabolism of vasodilator eicosanoids called epoxyeicosatrienoic acids, EETs, and is sexually dimorphic and suppressed by estrogen | Mus musculus |
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Release 2023.1 (January 2023)
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