Application | Comment | Organism |
---|---|---|
medicine | sEH is a potential therapeutic target in the treatment of ischemic stroke | Rattus norvegicus |
medicine | sEH is a potential therapeutic target in the treatment of ischemic stroke. Treatment of acute ischemic stroke with sEH inhibition, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene ephx2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C154Y | a naturally occuring polymorphism, the substitutions results in an enzyme with increased epoxide hydrolase activity, the mutation is associated with with ischemic stroke risk | Homo sapiens |
E470G | a naturally occuring polymorphism, the substitutions results in an enzyme with increased epoxide hydrolase activity, the mutation is associated with with ischemic stroke risk | Homo sapiens |
K55R | a naturally occuring polymorphism, the substitutions results in an enzyme with increased epoxide hydrolase activity, the mutation is associated with with ischemic stroke risk | Homo sapiens |
additional information | gene EPHX2 contains several naturally occuring polymorphisms within study populations, some of which resulted in non-synonymous amino acid substitutions | Homo sapiens |
R287Q | a naturally occuring polymorphism, the substitutions results in an enzyme with reduced epoxide hydrolase activity | Homo sapiens |
S402R | a naturally occuring polymorphism, the substitutions results in an enzyme with reduced epoxide hydrolase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
12-(3-adamantan-1-yl-ureido)dodecanoic acid | AUDA | Homo sapiens | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid | AUDA | Mus musculus | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid | AUDA | Rattus norvegicus | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester | AUDA-BE, displays improved bioavailability compared to AUDA | Homo sapiens | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester | AUDA-BE, displays improved bioavailability compared to AUDA, can be administered ip to improve stroke outcome in a mouse model of ischemia/reperfusion injury | Mus musculus | |
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester | AUDA-BE | Rattus norvegicus | |
dicyclohexylurea | - |
Homo sapiens | |
dicyclohexylurea | - |
Mus musculus | |
dicyclohexylurea | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Homo sapiens | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | EETs exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Homo sapiens | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
additional information | Mus musculus | EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview | ? | - |
? | |
additional information | Homo sapiens | EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34913 | gene EPHX2 | - |
Mus musculus | P34914 | gene EPHX2 | - |
Rattus norvegicus | P80299 | gene EPHX2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in vascular smooth muscle and endothelial cell layers, in white matter | Homo sapiens | - |
brain | in vascular smooth muscle and endothelial cell layersm in white matter. sEH in rodent brain is neither vascular nor glial, but rather neuronal. In brain parenchymal tissue, sEH is markedly expressed in neuronal cell bodies and processes, particularly within the cerebral cortex and striatum | Mus musculus | - |
brain cortex | - |
Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
glia | restricted primarily to oligodendrocytes in the white matter | Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | EETs exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation | Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
additional information | EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview | Mus musculus | ? | - |
? | |
additional information | EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |
SEH | - |
Homo sapiens |
SEH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
- |
Rattus norvegicus | dicyclohexylurea | |
0.000007 | - |
- |
Rattus norvegicus | 12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester |
General Information | Comment | Organism |
---|---|---|
malfunction | polymorphimsm in gene EPHX2 are associated with ischemic stroke risk. sEH inhibition and gene deletion reduce infarct size after focal cerebral ischemia in mice | Mus musculus |
malfunction | polymorphimsm in gene EPHX2 are associated with ischemic stroke risk. sEH inhibition and gene deletion reduce infarct size after focal cerebral ischemia in mice | Homo sapiens |
malfunction | polymorphimsm in gene EPHX2 are associated with ischemic stroke risk. sEH inhibition and gene deletion reduce infarct size after focal cerebral ischemia in mice | Rattus norvegicus |
additional information | enzyme inhibition protects against ischemic stroke, mechanism and cytoprotective, anti-inflammatory, and other effects, overview | Mus musculus |
additional information | enzyme inhibition protects against ischemic stroke, mechanism and cytoprotective, anti-inflammatory, and other effects, overview | Homo sapiens |
physiological function | soluble epoxide hydrolase is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids, EETs | Mus musculus |
physiological function | soluble epoxide hydrolase is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids, EETs | Homo sapiens |
physiological function | soluble epoxide hydrolase is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids, EETs | Rattus norvegicus |