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Literature summary for 3.3.2.10 extracted from

  • Oguro, A.; Fujita, N.; Imaoka, S.
    Regulation of soluble epoxide hydrolase (sEH) in mice with diabetes: high glucose suppresses sEH expression (2009), Drug Metab. Pharmacokinet., 24, 438-445.
    View publication on PubMed
Search for more literature for 3.3.2.10

Protein Variants

Protein Variants Comment Organism
additional information male mice lacking the sEH gene had lower systolic blood pressure Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview ?
-
 ?
additional information Mus musculus epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus P34914 streptozotocin-induced diabetic mice
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney distribution in proximal tubules but not in the glomerulus or other regions, immunohistochemic analysis Mus musculus
-
liver
-
 Homo sapiens
-
liver diabetes reduces the amount of sEH protein in the liver and insulin restored the level of protein Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview Homo sapiens ?
-
 ?
additional information epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens
SEH
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens high glucose and high concentration of reactive oxygen species suppresses sEH mRNA and protein expression in Hep-3B cells. Inhibition of NADPH oxidase inhibits the decrease in sEH by high glucose and the addition of hydrogen peroxide to Hep3B cells suppresses the expression of sEH down
Mus musculus high glucose levels suppress sEH expression in diabetic mouse liver, which is reversible by insulin down

General Information

General Information Comment Organism
malfunction diabetes is one of the main factors responsible for end-stage renal disease caused by impaired endothelium Homo sapiens
malfunction diabetes is one of the main factors responsible for end-stage renal disease caused by impaired endothelium Mus musculus
physiological function sEH is a xenobiotic-metabolizing enzyme that metabolizes epoxides to produce vicinal diols. Epoxyeicosatrienoic acids are substrates of sEH and have important roles in renal function such as ion transport and the proliferation of cells and the action of epoxyeicosatrienoic acids is important for maintaining renal and vascular homeostasis Homo sapiens
physiological function sEH is a xenobiotic-metabolizing enzyme that metabolizes epoxides to produce vicinal diols. Epoxyeicosatrienoic acids are substrates of sEH and have important roles in renal function such as ion transport and the proliferation of cells and the action of epoxyeicosatrienoic acids is important for maintaining renal and vascular homeostasis Mus musculus