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Literature summary for 3.3.2.10 extracted from

  • Keserue, B.; Barbosa-Sicard, E.; Schermuly, R.T.; Tanaka, H.; Hammock, B.D.; Weissmann, N.; Fisslthaler, B.; Fleming, I.
    Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition (2010), Cardiovasc. Res., 85, 232-240.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
sEH expression in HEK-293 cells under the control of the cytomegalo virus promoter, tissue expression analysis by real-time quantitative reverse transcription PCR Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-adamantyl-3-cyclohexylurea
-
 Homo sapiens
1-adamantyl-3-cyclohexylurea
-
 Mus musculus
cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
 Homo sapiens
cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
 Mus musculus
additional information the EET antagonist, 14,15-EEZE at 10 mM attenuates the increase in pulmonary artery pressure in the absence of the sEH inhibitor and completely prevents the increased constriction induced by 1-adamantyl-3-cyclohexylurea. Prolonged sEH inhibition results in significantly elevated serum levels of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids/dihydroxyeicosatrienoic acids but fails to affect the ratio of the right/left ventricle and septum Mus musculus
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
 Homo sapiens
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-
Mus musculus P34914 C57BL/6 mice
-
Mus musculus C57BL/6 P34914 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
lung immunohistochemical analysis showing the expression of the sEH in lungs from wild-type mice kept under normoxic conditions or after exposure to 21 days hypoxia, overview Mus musculus
-
lung sEH is expressed in the wall of pulmonary arteries, however, sEH expression is absent in samples from patients with pulmonary hypertension Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
additional information the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity Mus musculus ?
-
 ?
additional information the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity Homo sapiens ?
-
 ?
additional information the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus
SEH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction acute hypoxic vasoconstriction in sEH-/- mice is insensitive to sEH inhibition but inhibited by the epoxyeicosatrienoic acid antagonist, and chronic hypoxia induces an exaggerated pulmonary vascular remodelling. In wild-type mice, chronic sEH inhibition increases serum epoxyeicosatrienoic acid levels but fails to affect acute hypoxic vasoconstriction, right ventricle weight, pulmonary artery muscularization, or voluntary running distance Mus musculus
malfunction sEH expression is absent in samples from patients with pulmonary hypertension. As sEH inhibitors do not promote the development of pulmonary hypertension it seems likely that the N-terminal lipid phosphatase may play a role in the development of this disease Homo sapiens