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Literature summary for 3.3.2.10 extracted from

  • Zhang, L.N.; Vincelette, J.; Cheng, Y.; Mehra, U.; Chen, D.; Anandan, S.K.; Gless, R.; Webb, H.K.; Wang, Y.X.
    Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia (2009), Arterioscler. Thromb. Vasc. Biol., 29, 1265-1270.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
AR9276 a potent, orally bioavailable, ans selective sEH inhibitor, pharmacokinetics and clearance, overview. Lowers the cholesterol levels a nd attenuates abdominal aortic aneurysm formation. It also reduces lesions in thew aortic arch and nonliganted right carotid artery, but has no effect on ligation-induced vascular remodeling in the carotid artery, overview Mus musculus
additional information inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia. It downregulates the expression of proinflammatory mediators in the aortic tissue and in the blood Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
artery
-
 Mus musculus
-
blood
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
s-EH
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000016
-
-
 Mus musculus AR9276

General Information

General Information Comment Organism
additional information inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia Mus musculus